The nitration of proteins, lipids and DNA by peroxynitrite derivatives-chemistry involved and biological relevance

JM Pérez de la Lastra, CA Juan, FJ Plou… - Stresses, 2022 - mdpi.com
In recent years, much interest has been generated by the idea that nitrosative stress plays a
role in the aetiology of human diseases, such as atherosclerosis, inflammation, cancer, and …

Peroxynitrite: a potent oxidizing and nitrating agent

JP Kamat - 2006 - nopr.niscpr.res.in
Nitric oxide (NO.) reacts with superoxide (O 2-.) forming peroxynitrite (PXN)(ONOO-), a
strong oxidant which reacts with several biomolecules leading to enormous implications in …

Peroxynitrite—An ugly biofactor?

P Ascenzi, A Di Masi, C Sciorati, E Clementi - Biofactors, 2010 - Wiley Online Library
Cellular damage occurring under oxidative conditions has been ascribed mainly to the
formation of peroxynitrite (ONOOH/ONOO−) that originates from the reaction of NO• with …

Drugs modulating the biological effects of peroxynitrite and related nitrogen species

A Olmos, RM Giner, S Máñez - Medicinal Research Reviews, 2007 - Wiley Online Library
The term “reactive nitrogen species” includes nitrogen monoxide, commonly called nitric
oxide, and some other remarkable chemical entities (peroxynitrite, nitrosoperoxycarbonate …

Biochemistry of peroxynitrite and protein tyrosine nitration

G Ferrer-Sueta, N Campolo, M Trujillo… - Chemical …, 2018 - ACS Publications
Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

Peroxynitrite: an endogenous oxidizing and nitrating agent

C Ducrocq, B Blanchard, B Pignatelli… - Cellular and Molecular …, 1999 - Springer
Peroxynitrite, the reaction product between nitric oxide (• NO) and superoxide, has been
presumed to be a mediator of cellular and tissue injury in various pathological situations. It is …

[HTML][HTML] Role of peroxynitrite in the redox regulation of cell signal transduction pathways

L Liaudet, G Vassalli, P Pacher - Frontiers in bioscience: a journal …, 2009 - ncbi.nlm.nih.gov
Peroxynitrite is a potent oxidant and nitrating species formed from the reaction between the
free radicals nitric oxide and superoxide. An excessive formation of peroxynitrite represents …

Peroxynitrite and drug-dependent toxicity

A Denicola, R Radi - Toxicology, 2005 - Elsevier
Peroxynitrite is the product of the diffusion-controlled termination reaction between two
radicals, nitric oxide and superoxide and is a strong oxidant and nitrating intermediate …

[HTML][HTML] Fundamentals on the biochemistry of peroxynitrite and protein tyrosine nitration

S Bartesaghi, R Radi - Redox biology, 2018 - Elsevier
In this review we provide an analysis of the biochemistry of peroxynitrite and tyrosine
nitration. Peroxynitrite is the product of the diffusion-controlled reaction between superoxide …

Peroxynitrite, a stealthy biological oxidant

R Radi - Journal of Biological Chemistry, 2013 - ASBMB
Peroxynitrite is the product of the diffusion-controlled reaction of nitric oxide and superoxide
radicals. Peroxynitrite, a reactive short-lived peroxide with ap K a of 6.8, is a good oxidant …