Lidocaine suppresses the malignant behavior of gastric cancer cells via the c‑Met/c‑Src pathway

W Zeng, ZT Xing, MY Tan… - Experimental and …, 2021 - spandidos-publications.com
The present study was designed to investigate the role and mechanism of action behind the
action of lidocaine in gastric cancer cells. Lidocaine was tested for its potential role in …

Anti-tumor effects of lidocaine on human gastric cancer cells in vitro.

C YJ - Bratislava Medical Journal/Bratislavske Lekarske …, 2019 - search.ebscohost.com
Currently, there exists an urgent need to investigate the anti-cancer effects of lidocaine on
gastric cancer cells. The purpose of the present study was to evaluate the anti-tumor effects …

Lidocaine inhibits growth, migration and invasion of gastric carcinoma cells by up-regulation of miR-145

H Sui, A Lou, Z Li, J Yang - BMC cancer, 2019 - Springer
Background Gastric cancer receives considerable attention not only because it is the most
common cancer all through the world, but also because it's on the top third leading reason …

[PDF][PDF] Antiproliferative and apoptotic effects of lidocaine on human hepatocarcinoma cells. A preliminary study

A Jurj, C Tomuleasa, TT Tat… - J Gastrointestin …, 2017 - researchgate.net
ABSTRACT Background & Aims: It is now well documented that certain anesthetic
techniques may influence long term outcome in cancer patients undergoing surgery. More …

Lidocaine induces epithelial‑mesenchymal transition and aggravates cancer behaviors in non‑small cell lung cancer A549 cells

WH Hsieh, SW Liao, SM Chan, JD Hou… - Oncology …, 2023 - spandidos-publications.com
The effects of clinically relevant concentrations of lidocaine on epithelial‑mesenchymal
transition (EMT) and associated lung cancer behaviors have rarely been investigated. The …

Lidocaine combined with general anesthetics impedes metastasis of breast cancer cells via inhibition of TGF-β/Smad-mediated EMT signaling by reprogramming …

BS Han, S Ko, MS Park, YJ Lee, SE Kim, P Lee… - International …, 2024 - Elsevier
Surgical resection is the best-known approach for breast cancer treatment. However, post-
operative metastases increase the rate of death. The potential effect of anesthetic drugs on …

Lidocaine inhibits melanoma cell proliferation by regulating ERK phosphorylation

J Chen, Z Jiao, A Wang, W Zhong - Journal of cellular …, 2019 - Wiley Online Library
The melanoma is responsible for the majority of all skin cancer–related deaths worldwide.
Evidence suggests that local anesthetics provide some benefit in the treatment of cancer via …

Lidocaine Induces Apoptosis and Suppresses Tumor Growth in Human Hepatocellular Carcinoma Cells In Vitro and in a Xenograft Model In Vivo

W Xing, DT Chen, JH Pan, YH Chen, Y Yan, Q Li… - …, 2017 - pubs.asahq.org
Background Recent epidemiologic studies have focused on the potential beneficial effects of
regional anesthetics, and the differences in cancer prognosis may be the result of …

Procaine abrogates the epithelial-mesenchymal transition process through modulating c-met phosphorylation in hepatocellular carcinoma

MH Yang, CD Mohan, A Deivasigamani… - Cancers, 2022 - mdpi.com
Simple Summary Epithelial-mesenchymal transition (EMT) is a vital process that leads to the
dissemination of tumor cells to distant organs and promotes cancer progression. Aberrant …

Lidocaine inhibits proliferation and induces apoptosis in colorectal cancer cells by upregulating mir-520a-3p and targeting EGFR

X Qu, L Yang, Q Shi, X Wang, D Wang, G Wu - Pathology-Research and …, 2018 - Elsevier
Lidocaine is a conventional local anesthetic which is shown antiproliferative of colorectal
cancer (CRC) in patients. MicroRNAs (miRNAs) have been consistently demonstrated to be …