Aging is inevitable, but the inherently and genetically programmed aging process is
markedly influenced by environmental factors. All organisms are constantly exposed to …

Significance: Central nervous system (CNS) diseases are disorders of the brain and/or
spinal cord and include neurodegenerative diseases such as Alzheimer's disease …

Oxidative stress is defined as an imbalance between production of free radicals and reactive
metabolites or [reactive oxygen species (ROS)] and their elimination by through protective …

Extracellular and intracellular oxidants or electrophiles are key contributors to the damages
in cellular macromolecules, such as DNA, proteins and lipids. Nrf2 is a master transcription …

Abstract Nrf2 (NF-E2-related factor 2) is a master regulator of cellular responses against
environmental stresses. Nrf2 induces the expression of detoxification and antioxidant …

The Keap1–Nrf2 pathway plays a crucial role in determining the sensitivity of cells to
chemical and/or oxidative insults by regulating the basal and inducible expression of …

The transcription factor nuclear factor-erythroid 2 p45-related factor 2 (Nrf2, with gene called
NFE2L2) is a master regulator of the antioxidant response. In the last decade, interest has …

Abstract Nrf2 (NFE2L2–nuclear factor (erythroid-derived 2)-like 2) is a transcription factor,
which is repressed by interaction with a redox-sensitive protein Keap1 (Kelch-like ECH …

Reactive oxygen species (ROS) and products of their reactions with cellular
macromolecules such as unsaturated fatty acids have been implicated to be important …

Since eukaryotic cells constantly encounter various environmental insults, they have
evolved defense mechanisms to cope with toxicant-and carcinogen-induced oxidative stress …