Six1 is a developmental transcriptional regulator frequently overexpressed in human tumors.
Recent results show that SIX1 also acts as a repressor of cell senescence, an …

Cellular senescence is an antiproliferative response with essential functions in tumor
suppression and tissue homeostasis. Here we show that SIX1, a member of the SIX family of …

In the past two decades, many studies have shown that sine oculis homeobox 1 (Six1) is a
powerful regulator of organogenesis and disease, with important roles in tumorigenesis; …

Abstract Sine oculis homeoprotein 1 (SIX1), a prominent representative of the homeodomain
transcription factors within the SIX family, has attracted significant interest owing to its role in …

Inappropriate activation of developmental pathways is a well-recognized tumor-promoting
mechanism. Here we show that overexpression of the homeoprotein Six1, normally a …

The Six1 homeoprotein plays a critical role in expanding progenitor populations during
normal development via its stimulation of proliferation and inhibition of apoptosis …

Six1 is one of the transcription factors that act as master regulators of development and are
frequently dysregulated in cancers. However, the role of Six1 in pancreatic cancer is not …

The Six1 homeodomain protein is a developmental transcription factor that has been
implicated in tumor onset and progression. Our recent work shows that Six1 overexpression …

Renal cell carcinoma (RCC) accounts for 2–3% of adult malignant tumors, and the incidence
of RCC worldwide has increased by about 2% over the past two decades. The homeobox …

Abstract Sineoculis homeobox homolog 1 (Six1) is one of the transcription factors that act as
master regulators of development and is frequently dysregulated in cancers. However, the …