Multiple sclerosis (MS) is an inflammatory and demyelinating condition of the CNS,
characterized by perivascular infiltrates composed largely of T lymphocytes and …

While no single model can exactly recapitulate all aspects of multiple sclerosis (MS), animal
models are essential in understanding the induction and pathogenesis of the disease and to …

Since its first description, experimental autoimmune encephalomyelitis, originally
designated experimental allergic encephalitis (EAE), has been proposed as animal model to …

Multiple sclerosis is considered an autoimmune disease, which leads to inflammatory
demyelinating plaques in the white matter of the central nervous system (CNS). Recent …

Multiple sclerosis (MS) is a spontaneous, acquired, inflammatory demyelinating disease of
the human CNS. Because it involves a complex interaction between two of the most intricate …

Multiple sclerosis (MS) is a chronic neurological disorder of the central nervous system
(CNS) leading to progressive accumulation of neurological deficits arising from recurrent …

Experimental autoimmune encephalomyelitis (EAE) is still the most widely accepted animal
model of multiple sclerosis (MS). Different types of EAE have been developed in order to …

In view of disease heterogeneity of multiple sclerosis and limited access to ex vivo
specimens, different approaches must be undertaken to better understand disease …

The high failure rate of immunotherapies in multiple sclerosis (MS) clinical trials
demonstrates problems in translating new treatment concepts from animal models to the …

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) in which myelin becomes the target of attack by autoreactive T cells. The immune …