A review of HER2 overexpression and somatic mutations in cancers
M Galogre, D Rodin, M Pyatnitskiy… - Critical Reviews in …, 2023 - Elsevier
Abstract The Human Epidermal Growth Factor Receptor (HER) proteins family, which
includes HER2, are membrane-bound receptors that activate many intracellular pathways …
includes HER2, are membrane-bound receptors that activate many intracellular pathways …
HER3 comes of age: new insights into its functions and role in signaling, tumor biology, and cancer therapy
MR Campbell, D Amin, MM Moasser - Clinical Cancer Research, 2010 - AACR
The human epidermal growth family (HER) of tyrosine kinase receptors underlies the
pathogenesis of many types of human cancer. The oncogenic functions of three of the HER …
pathogenesis of many types of human cancer. The oncogenic functions of three of the HER …
The role of HER3, the unpretentious member of the HER family, in cancer biology and cancer therapeutics
DN Amin, MR Campbell, MM Moasser - Seminars in cell & developmental …, 2010 - Elsevier
Many types of human cancer are characterized by deregulation of the human epidermal
growth factor receptor (HER) family of tyrosine kinase receptors. In some cancers, genomic …
growth factor receptor (HER) family of tyrosine kinase receptors. In some cancers, genomic …
[HTML][HTML] Activating HER2 mutations as emerging targets in multiple solid cancers
CM Connell, GJ Doherty - ESMO open, 2017 - Elsevier
The epidermal growth factor receptor (EGFR) family of transmembrane receptor tyrosine
kinases activates signalling pathways regulating cellular proliferation and survival. HER2 is …
kinases activates signalling pathways regulating cellular proliferation and survival. HER2 is …
Molecular pathways: HER3 targeted therapy
K Gala, S Chandarlapaty - Clinical cancer research, 2014 - AACR
The HER family of receptor tyrosine kinases, including EGF receptor (EGFR), HER2, HER3,
and HER4, transduce growth-promoting signals in response to ligand binding to their …
and HER4, transduce growth-promoting signals in response to ligand binding to their …
Clinicopathologic features and treatment advances in cancers with HER2 alterations
HER2 is one of the most important proteins of the epidermal growth factor receptor (EGFR)
family, whose alterations include amplification, overexpression and gene mutation. Growing …
family, whose alterations include amplification, overexpression and gene mutation. Growing …
Human epidermal growth factor receptor 2 (HER2) in cancers: overexpression and therapeutic implications
N Iqbal, N Iqbal - Molecular biology international, 2014 - Wiley Online Library
Human epidermal growth factor receptor 2 (HER2) is a member of the epidermal growth
factor receptor family having tyrosine kinase activity. Dimerization of the receptor results in …
factor receptor family having tyrosine kinase activity. Dimerization of the receptor results in …
[HTML][HTML] HER3 alterations in cancer and potential clinical implications
Simple Summary HER3 is a member of the HER family. In the past decade, HER3 has been
recognized as an important protein in allowing tumors to grow unchecked. This review …
recognized as an important protein in allowing tumors to grow unchecked. This review …
Prevalence and role of HER2 mutations in cancer
HER2 activating mutations act as oncogenic drivers in various cancer types. In the clinic,
they can be identified by next generation sequencing (NGS) in either tumor biopsies or …
they can be identified by next generation sequencing (NGS) in either tumor biopsies or …
The HER family and cancer: emerging molecular mechanisms and therapeutic targets
NV Sergina, MM Moasser - Trends in molecular medicine, 2007 - cell.com
The human epidermal growth factor receptor (HER) family of transmembrane tyrosine
kinases regulates diverse cellular functions in response to extracellular ligands. The …
kinases regulates diverse cellular functions in response to extracellular ligands. The …