There are a number of features of endocrine-disrupting chemicals (EDCs) that distinguish
them from traditional toxicants. One such attribute is the ability of EDCs to induce …

For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged traditional
concepts in toxicology, in particular the dogma of “the dose makes the poison,” because …

Vandenberg et al.(2012) claim that “most if not all [endocrine-disrupting chemicals (EDCs)]
are likely to have low-dose effects” and “nonmonotonicity is a common occurrence after …

A large number of diverse nonsteroidal chemicals, referred to as xenoestrogens, bind to the
estrogen receptor (ER) and evoke biological responses. The activity of most xenoestrogens …

The concept of a threshold of adversity in toxicology is neither provable nor disprovable. As
such, it is not a scientific question but a theoretical one. Yet, the belief in thresholds has led …

This chapter begins with an overview of the extent to which endocrine-disrupting chemicals
(EDCs) can enter human tissues from environmental exposure. Retention of EDCs in body …

Abstract Early in 2013, the World Health Organization (WHO) released a 2012 update to the
2002 State of the Science of Endocrine Disrupting Chemicals. Several significant concerns …

In the fields of endocrinology and toxicology, there are ongoing debates about whether
endocrine disrupting chemicals (EDCs) produce non-monotonic dose responses. This type …

Regulatory agencies around the world depend on standardized testing approaches to
evaluate environmental chemicals for endocrine disrupting properties. The US …

Potential health effects from chemicals that disrupt endocrine function pose an
environmental health concern because of their ability to interfere with normal hormone …