Objectives HLA-B27 and the endoplasmic reticulum aminopeptidase 1 (ERAP1) and ERAP2
genes are predisposing factors for AS. A single nucleotide polymorphism (SNP) in the …

Objectives The functional interaction of endoplasmic reticulum aminopeptidase 1 (ERAP1)
with human leucocyte antigen (HLA)-B* 27 could be important in the pathogenesis of …

Objective The basic mechanisms underlying the pathogenesis of ankylosing spondylitis (AS)
remain unresolved. We previously reported an association of the single‐nucleotide …

Objective Endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) variants contribute to the
risk of ankylosing spondylitis in HLA-B27 positive individuals, implying a disease-related …

Objective. The association of non-MHC genes with AS has been recently suggested. We
aimed to investigate the association of the ERAP1, IL23R and TNFSF15 regions and the …

The mechanism by which human leukocyte antigen B27 (HLA-B27) contributes to
ankylosing spondylitis (AS) remains unclear. Genetic studies demonstrate that association …

We investigated two nonsynonymous variants (rs30187 and rs27044) of ERAP1 gene in
HLA‐B27 positive individuals (150 spondyloarthritis and 108 controls) and in general …

Background We aimed to assess if Endoplasmic reticulum aminopeptidase 1 (ERAP1)
polymorphisms might impress Human leukocyte antigen (HLA)-B27-free heavy chains …

Ankylosing spondylitis (AS) is a chronic systemic arthritic disease that leads to significant
disability and loss of quality of life in the∼ 0.5% of the worldwide human population it …

Objective Human leucocyte antigen (HLA)-B27 and endoplasmic reticulum aminopeptidase
1 (ERAP1) are strongly associated with ankylosing spondylitis (AS). ERAP1 is a key …