[HTML][HTML] Noninvasive proteomic biomarkers for alcohol-related liver disease
Alcohol-related liver disease (ALD) is a major cause of liver-related death worldwide, yet
understanding of the three key pathological features of the disease—fibrosis, inflammation …
understanding of the three key pathological features of the disease—fibrosis, inflammation …
Plasma proteome profiling discovers novel proteins associated with non‐alcoholic fatty liver disease
Non‐alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to
cirrhosis with limited treatment options. As the liver secretes most of the blood plasma …
cirrhosis with limited treatment options. As the liver secretes most of the blood plasma …
[HTML][HTML] A proteo-transcriptomic map of non-alcoholic fatty liver disease signatures
Non-alcoholic fatty liver disease (NAFLD) is a common, progressive liver disease strongly
associated with the metabolic syndrome. It is unclear how progression of NAFLD towards …
associated with the metabolic syndrome. It is unclear how progression of NAFLD towards …
The human liver‐specific proteome defined by transcriptomics and antibody‐based profiling
C Kampf, A Mardinoglu, L Fagerberg… - The FASEB …, 2014 - Wiley Online Library
Human liver physiology and the genetic etiology of the liver diseases can potentially be
elucidated through the identification of proteins with enriched expression in the liver. Here …
elucidated through the identification of proteins with enriched expression in the liver. Here …
Dynamic human liver proteome atlas reveals functional insights into disease pathways
Deeper understanding of liver pathophysiology would benefit from a comprehensive
quantitative proteome resource at cell type resolution to predict outcome and design …
quantitative proteome resource at cell type resolution to predict outcome and design …
[PDF][PDF] Serum proteomics and biomarker discovery across the spectrum of nonalcoholic fatty liver disease
LN Bell, JL Theodorakis, R Vuppalanchi… - …, 2010 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD), ranging from relatively benign simple steatosis to
progressive nonalcoholic steatohepatitis (NASH) and fibrosis, is an increasingly common …
progressive nonalcoholic steatohepatitis (NASH) and fibrosis, is an increasingly common …
[HTML][HTML] Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease
Background & Aims Non-alcoholic fatty liver disease (NAFLD) is a progressive liver disease
with potentially severe complications including cirrhosis and hepatocellular carcinoma …
with potentially severe complications including cirrhosis and hepatocellular carcinoma …
A blood-based biomarker panel (NIS4) for non-invasive diagnosis of non-alcoholic steatohepatitis and liver fibrosis: a prospective derivation and global validation …
SA Harrison, V Ratziu, J Boursier… - The lancet …, 2020 - thelancet.com
Background Non-invasive tests that can identify patients with non-alcoholic steatohepatitis
(NASH) at higher risk of disease progression are lacking. We report the development and …
(NASH) at higher risk of disease progression are lacking. We report the development and …
[HTML][HTML] Development and validation of an ensemble machine learning framework for detection of all-cause advanced hepatic fibrosis: a retrospective cohort study
Background Cirrhosis is the result of advanced scarring (or fibrosis) of the liver, and is often
diagnosed once decompensation with associated complications has occurred. Current non …
diagnosed once decompensation with associated complications has occurred. Current non …
[HTML][HTML] Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts
Background Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes
serious health complications in individuals with and without type 2 diabetes (T2D). Early …
serious health complications in individuals with and without type 2 diabetes (T2D). Early …