Clofibrate, a peroxisome proliferator–activated receptor-alpha (PPARα) agonist, and its molecular mechanisms of action against sodium fluoride–induced toxicity

AA Oyagbemi, OA Adejumobi, TA Jarikre… - … Trace Element Research, 2022 - Springer
Sodium fluoride (NaF) is one of the neglected environmental pollutants. It is ubiquitously
found in the soil, water, and environment. Interestingly, fluoride has been extensively utilized …

Effect of sodium fluoride on the proliferation and gene differential expression in human RPMI8226 Cells

H He, H Wang, Y Jiao, C Ma, H Zhang… - Biological trace element …, 2015 - Springer
Although fluoride is known to reduce the incidence of caries, chronic excessive fluoride
exposure can impair human health, even resulting in fluorosis. Now the underlying …

Sodium fluoride induces hypertension and cardiac complications through generation of reactive oxygen species and activation of nuclear factor kappa beta

AA Oyagbemi, TO Omobowale… - Environmental …, 2017 - Wiley Online Library
Human exposure to sodium fluoride through its daily usage is almost inevitable.
Cardiovascular and renal dysfunction has been associated with fluoride toxicity. Therefore …

Quercetin attenuates hypertension induced by sodium fluoride via reduction in oxidative stress and modulation of HSP 70/ERK/PPARγ signaling pathways

AA Oyagbemi, TO Omobowale, OE Ola‐Davies… - Biofactors, 2018 - Wiley Online Library
Hypertension is one of the silent killers in the world with high mortality and morbidity. The
exposure of humans and animals to fluoride and/or fluoride containing compounds is almost …

Attenuation of perfluorooctanoic acid-induced testicular oxidative stress and apoptosis by quercetin in mice

Y Yuan, S Ge, Z Lv, M Wu, H Kuang, B Yang, J Yang… - RSC …, 2017 - pubs.rsc.org
Perfluorooctane acid (PFOA), a persistent environmental pollutant, is considered to cause
adverse health effects. In the present study, we investigated the attenuating effect of …

Protective effect of Tamarindus indica fruit pulp extract on collagen content and oxidative stress induced by sodium fluoride in the liver and kidney of rats

AR Gupta, S Dey, M Saini, D Swarup - … & Environmental Chemistry, 2013 - Taylor & Francis
Fluorosis is a serious public health problem in many parts of the world. The generation of
reactive oxygen species and lipid peroxidation has been considered to play an important …

Rutin potentially attenuates fluoride-induced oxidative stress-mediated cardiotoxicity, blood toxicity and dyslipidemia in rats

V Umarani, S Muvvala, A Ramesh… - Toxicology …, 2015 - Taylor & Francis
This study was undertaken to evaluate cardio protective effect of rutin against sodium
fluoride (NaF)-induced oxidative stress-mediated cardiotoxicity and blood toxicity. Cardiac …

Effect of hesperidin on fluoride‐induced neurobehavioral and biochemical changes in rats

P Jaiswal, M Mandal, A Mishra - Journal of Biochemical and …, 2020 - Wiley Online Library
Fluoride is the second largest contaminant of drinking water. Fluoride toxicity is a major
concern in the endemic areas where a high amount of fluoride is present in ground water …

Toxic effects of fluoride in intestinal epithelial cells and the mitigating effect of methanol extract of coconut haustorium by enhancing de novo glutathione biosynthesis

JT Job, R Rajagopal, A Alfarhan, V Ramesh… - Environmental …, 2021 - Elsevier
Fluoride ions are an important environmental contaminant and pollutant found in a wide
variety of environmental conditions. The fluoride in drinking water is evident to induce toxic …

[PDF][PDF] Fluoride contamination, toxicity and its potential therapeutic agents

P Rajak, S Roy, S Khatun, M Mandi… - Toxicology …, 2023 - researchgate.net
Fluoride is the thirteenth most abundant element in the earth's crust. It is highly
electronegative and distributed ubiquitously in nature. During weathering of rocks and soil …