Diet-induced adipose tissue expansion is mitigated in mice with a targeted inactivation of mesoderm specific transcript (Mest)

RP Anunciado-Koza, J Manuel, RL Mynatt, J Zhang… - PLoS …, 2017 - journals.plos.org
Interindividual variation of white adipose tissue (WAT) expression of mesoderm specific
transcript (Mest), a paternally-expressed imprinted gene belonging to the α/β-hydrolase fold …

Inter-individual variation of dietary fat-induced mesoderm specific transcript in adipose tissue within inbred mice is not caused by altered promoter methylation

RA Koza, P Rogers, LP Kozak - Epigenetics, 2009 - Taylor & Francis
Mesoderm specific transcript (Mest), an imprinted gene associated with fat mass expansion
under conditions of positive energy balance, shows highly variable expression (~ 80-fold) in …

Mesoderm-specific transcript (MEST) is a negative regulator of human adipocyte differentiation

M Karbiener, C Glantschnig, DF Pisani… - International journal of …, 2015 - nature.com
Background: A growing body of evidence suggests that many downstream pathologies of
obesity are amplified or even initiated by molecular changes within the white adipose tissue …

Interindividual differences of dietary fat‐inducible Mest in white adipose tissue of C57BL/6J mice are not heritable

RVP Anunciado‐Koza, H Yin, CL Bilodeau, D Cooke… - …, 2024 - Wiley Online Library
Objective Differences in white adipose tissue (WAT) expression of mesoderm‐specific
transcript (Mest) in C57BL6/J mice fed a high‐fat diet (HFD) are concomitant with and …

Molecular correlates of fat mass expansion in C57BL/6J mice after short‐term exposure to dietary fat

RP Anunciado‐Koza, J Manuel… - Annals of the New York …, 2016 - Wiley Online Library
Heterogeneity of obesity within a population of inbred mice fed an obesogenic high‐fat diet
(HFD) is associated with changes of gene expression in white adipose tissue (WAT). One …

Mouse mesoderm-specific transcript inhibits adipogenic differentiation and induces trans-differentiation into hepatocyte-like cells in 3T3-L1 preadiocytes

Y Kadota, T Kawakami, M Sato, S Suzuki - BMC Research Notes, 2022 - Springer
Objective The mesoderm-specific transcript (Mest) is an imprinted gene that is transcribed
from the paternal allele. It is a marker of adipose tissue expansion; however, it is uncertain …

Mest/Peg1 imprinted gene enlarges adipocytes and is a marker of adipocyte size

M Takahashi, Y Kamei, O Ezaki - American Journal of …, 2005 - journals.physiology.org
Obesity is a common and serious metabolic disorder in the developed world that is
occasionally accompanied by type II diabetes, atherosclerosis, hypertension, and …

[HTML][HTML] Mesoderm-specific transcript is associated with fat mass expansion in response to a positive energy balance

L Nikonova, RA Koza, T Mendoza, PM Chao… - The FASEB …, 2008 - ncbi.nlm.nih.gov
A 50-fold variation in mRNA and protein levels of the mesoderm-specific transcript gene
(Mest) in white fat of C57BL/6J (B6) mice fed an obesogenic diet is positively correlated with …

Gene expression of mesoderm-specific transcript is upregulated as preadipocytes differentiate to adipocytes in vitro

Y Kadota, M Yanagawa, T Nakaya, T Kawakami… - The journal of …, 2012 - Springer
Mesoderm-specific transcript (Mest) is a distinct gene associated with adipocyte
differentiation and proliferation. The mechanisms regulating expression of the Mest gene are …

Identification of Mest/Peg1 gene expression as a predictive biomarker of adipose tissue expansion sensitive to dietary anti-obesity interventions

A Voigt, J Ribot, AG Sabater, A Palou, ML Bonet… - Genes & nutrition, 2015 - Springer
Food components with anti-obesity properties are commonly evaluated using mouse models
of diet-induced obesity. The ability of these components to reduce or prevent white adipose …