Background Early cancer detection could identify tumors at a time when outcomes are
superior and treatment is less morbid. This prospective case-control sub-study (from …

Background Early detection of cancer offers the opportunity to identify candidates when
curative treatments are achievable. The THUNDER study (THe UNintrusive Detection of …

Background Targeted methylation sequencing of plasma cell-free DNA (cfDNA) has a
potential to expand liquid biopsies to patients with tumors without detectable oncogenic …

Multimodal epigenetic characterization of cell-free DNA (cfDNA) could improve the
performance of blood-based early cancer detection. However, integrative profiling of cfDNA …

Purpose: We recently reported the development of a cell-free DNA (cfDNA) targeted
methylation (TM)-based sequencing approach for a multi-cancer early detection (MCED) test …

Background Our previous discovery work identified whole-genome bisulfite sequencing as
outperforming whole-genome and targeted sequencing approaches for multi-cancer …

Cancer-specific DNA methylation from the tumor derived fraction of cell free DNA found in
blood samples could be used for minimally invasive detection and monitoring of cancer. The …

Early cancer detection by cell-free DNA faces multiple challenges: low fraction of tumor cell-
free DNA, molecular heterogeneity of cancer, and sample sizes that are not sufficient to …

Carcinogenesis is accompanied by widespread DNA methylation changes within the cell.
These changes are characterized by a globally hypomethylated genome with focal …

Screening for early‐stage disease is vital for reducing colorectal cancer (CRC)‐related
mortality. Methylation of circulating tumor DNA has been previously used for various types of …