In the last two decades, the amyloid hypothesis, ie, the abnormal accumulation of toxic Aβ
assemblies in the brain, has been considered the mainstream concept sustaining research …

Protein misfolding and metal ion dyshomeostasis are believed to underlie numerous
neurodegenerative diseases, including Alzheimer's disease (AD). The pathological hallmark …

The so-called amyloid hypothesis, that the accumulation and deposition of oligomeric or
fibrillar amyloid β (Aβ) peptide is the primary cause of Alzheimer's disease (AD), has been …

Alzheimer's disease (AD) is characterized by two major pathological lesions in the brain,
amyloid plaques and neurofibrillary tangles (NFTs) composed mainly of amyloid-β (Aβ) …

Over the past 100 years, there has been an exponential increase in our understanding of the
underlying pathology of Alzheimer's disease (AD). This growth in knowledge has largely …

The “Amyloid Cascade Hypothesis” has dominated the Alzheimer's disease (AD) field in the
last 25 years. It posits that the increase of amyloid-ß (Aß) is the key event in AD that triggers …

Alzheimer's disease (AD) is a progressive age-related neurodegenerative disorder with
distinct neuropathological features. Extracellular plaques, consisting of aggregated amyloid …

This review describes interactions between the amyloid‐β peptide (Aβ) involved in
Alzheimer's disease (AD) and endogenous metal ions and proteins, with an emphasis on …

Amyloid-β and tau are the two hallmark proteins in Alzheimer's disease. Although both
amyloid-β and tau have been extensively studied individually with regard to their separate …

It is estimated that Alzheimer's disease (AD) strikes 5% of people over the age of 65. In
Western countries, this number was 15% in the mid 1990s and is estimated to exceed 20 …