Background: Marijuana extracts (cannabinoids) have been used for several millennia for
pain treatment. Regarding the site of action, cannabinoids are highly promiscuous …

GPR55 has recently attracted much attention as another member of the cannabinoid family,
potentially explaining physiological effects that are non-CB1/CB2 mediated. However, the …

It has been postulated that the G protein-coupled receptor, GPR55, is a third cannabinoid
receptor. Given that the ligands at the CB1 and CB2 receptors are effective analgesic and …

G protein-coupled receptor 55 (GPR55) shares numerous cannabinoid ligands with CB1
and CB2 receptors despite low homology with those classical cannabinoid receptors. The …

Despite sharing little homology (10–15%) with cannabinoid-1 (CB1) and cannabinoid-2
(CB2) receptors, the G protein-coupled receptor 55 (GPR55) was initially thought to be a …

Given the vast therapeutic potential of the endocannabinoid system, the revelation of a novel
cannabinoid-sensitive target was treated with great excitement. The orphan G-protein …

In the last decade, accumulated evidence highlighted that GPR55 might be activated by
several classical cannabinoid ligands, making this orphan receptor the main candidate to be …

The G-protein coupled receptor GPR55 has been postulated to serve as a novel
cannabinoid receptor. A previous report indicated that GPR55 knockout mice fail to develop …

The endocannabinoid system (ECS) has been shown to be of great importance in the
regulation of numerous physiological and pathological processes. To date, two Class A G …

GPR18 is a G-protein-coupled receptor that belongs to the orphan class A family. Even
though it shares low sequence homology with the cannabinoid receptors CB1R and CB2R …