Apolipoprotein E and atherosclerosis: beyond lipid effect
J Davignon - Arteriosclerosis, thrombosis, and vascular biology, 2005 - Am Heart Assoc
In humans, apolipoprotein E (apoE) is a polymorphic multifunctional protein. 1 It is coded by
three alleles (2, 3, 4) of a modulator gene (level, variability, and susceptibility gene) at the …
three alleles (2, 3, 4) of a modulator gene (level, variability, and susceptibility gene) at the …
Apolipoprotein E and atherosclerosis: insight from animal and human studies
J Davignon, JS Cohn, L Mabile, L Bernier - Clinica Chimica Acta, 1999 - Elsevier
Major advances have been made in our understanding of the role of apolipoprotein E
(apoE) in the onset and development of atherosclerosis. Increasing evidence from both …
(apoE) in the onset and development of atherosclerosis. Increasing evidence from both …
Apolipoprotein E polymorphism and atherosclerosis
G Kolovou, D Daskalova, DP Mikhailidis - Angiology, 2003 - journals.sagepub.com
The relationship between apolipoprotein (apo) E and vascular disease has been the subject
of a considerable amount of research. However, this relationship is far from clearly defined …
of a considerable amount of research. However, this relationship is far from clearly defined …
ApoE in atherosclerosis: a protein with multiple hats
LK Curtiss - Arteriosclerosis, thrombosis, and vascular biology, 2000 - Am Heart Assoc
Apolipoprotein (apo) E, which is present in plasma lipoproteins that carry dietary and liver-
derived cholesterol, plays a protective role in atherosclerosis. 1 ApoE plays a requisite role …
derived cholesterol, plays a protective role in atherosclerosis. 1 ApoE plays a requisite role …
Apolipoprotein E in cardiovascular diseases: novel aspects of an old-fashioned enigma
The presence of different APOE isoforms represents a well-known risk factor for
cardiovascular diseases. Besides the pleiotropic effects of APOE polymorphism on heart …
cardiovascular diseases. Besides the pleiotropic effects of APOE polymorphism on heart …
The underlying molecular mechanism of apolipoprotein E polymorphism: relationships to lipid disorders, cardiovascular disease, and Alzheimer's disease
JH Contois, DE Anamani, GJ Tsongalis - Clinics in laboratory medicine, 1996 - Elsevier
Apolipoprotein E (apo E) polymorphism has important clinical correlates, including disorders
of lipoprotein metabolism and atherosclerosis. This article provides a detailed methodology …
of lipoprotein metabolism and atherosclerosis. This article provides a detailed methodology …
Apolipoprotein E: possible therapeutic target for atherosclerosis
L Bocksch, T Stephens, A Lucas… - Current Drug Targets …, 2001 - ingentaconnect.com
Human apolipoprotein E (apoE) consists of a single polypeptide chain with 299 amino acids
and is best known for its role in the transport of cholesterol and other lipids between …
and is best known for its role in the transport of cholesterol and other lipids between …
Apolipoprotein E gene variants and risk of coronary heart disease: a meta‐analysis
M Xu, J Zhao, Y Zhang, X Ma, Q Dai… - BioMed Research …, 2016 - Wiley Online Library
Objectives. Apo E genes involved in lipoprotein synthesis and metabolism are considered
one of the candidates to CHD. However, the results remain conflicting. Methods. We …
one of the candidates to CHD. However, the results remain conflicting. Methods. We …
Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review
JE Eichner, ST Dunn, G Perveen… - American journal of …, 2002 - academic.oup.com
This review examines the association between the apolipoprotein (apo) ε gene
polymorphism (or its protein product (apo E)), metabolic regulation of cholesterol, and …
polymorphism (or its protein product (apo E)), metabolic regulation of cholesterol, and …
Apolipoprotein E in lipoprotein metabolism, health and cardiovascular disease
AD Marais - Pathology, 2019 - Elsevier
Summary Apolipoprotein E (apoE), a 34 kDa circulating glycoprotein of 299 amino acids,
predominantly synthesised in the liver, associates with triglyceride-rich lipoproteins to …
predominantly synthesised in the liver, associates with triglyceride-rich lipoproteins to …