Aberrant immune responses represent the underlying cause of central nervous system
(CNS) autoimmunity, including multiple sclerosis (MS). Recent evidence implicated the …

Factor XII (FXII) becomes a serine protease when blood is exposed to artificial medical
surfaces or when pathologic surfaces arise in disease states leading to its autoactivation …

Multiple sclerosis (MS) is the most common causes of non-traumatic disability in young
adults worldwide. MS pathophysiologies include the formation of inflammatory lesions …

Autoimmunity and macrophage recruitment into the central nervous system (CNS) are
critical determinants of neuroinflammatory diseases. However, the mechanisms that drive …

Factor XII (FXII) is the zymogen of serine protease, factor XIIa (FXIIa). FXIIa enzymatic
activities have been extensively studied and FXIIa inhibition is emerging as a promising …

A hypercoagulable state, chronic inflammation, and increased risk of venous thrombosis and
stroke are prominent features in patients with sickle cell disease (SCD). Coagulation factor …

Coagulation factor XII (FXII) deficiency is associated with decreased neutrophil migration,
but the mechanisms remain uncharacterized. Here, we examine how FXII contributes to the …

Blood coagulation factor XI (FXI) is an established risk factor for acute ischemic stroke (AIS)
and thrombosis, but is also needed for normal hemostasis. Contact factor XII (FXII), an …

Coagulation factor XII (FXII, Hageman factor) is a plasma protease that in its active form
(FXIIa) initiates the procoagulant and proinflammatory contact system. This name arises from …

Perivascular microglia activation is a hallmark of inflammatory demyelination in multiple
sclerosis (MS), but the mechanisms underlying microglia activation and specific strategies to …