Background and purpose White matter (WM) damage is the main target of hereditary spastic
paraplegia (HSP), but mounting evidence indicates that genotype‐specific grey matter (GM) …

BACKGROUND AND PURPOSE: Spinal cord damage is a hallmark of hereditary spastic
paraplegias, but it is still not clear whether specific subtypes of the disease have distinctive …

To determine the cortical mechanism that underlies the cognitive impairment and motor
disability in hereditary spastic paraplegia (HSP), nine HSP patients from a Chinese family …

Hereditary spastic paraplegias (HSP) are a group of clinically and genetically
heterogeneous disorders with the hallmark of progressive spastic gait disturbance. We used …

Mutations in the SPG4 gene (SPG4-HSP) are the most frequent cause of hereditary spastic
paraplegia, but the extent of the neurodegeneration related to the disease is not yet known …

The goal of this work was to assess brain structural and metabolic abnormalities of subjects
with SPG11 and their relevance to clinical disability by using quantitative magnetic …

Hereditary spastic paraplegia (HSP) linked to the spastic gait gene 4 (SPG4) is
controversial, as the “pure” form traditionally has been considered confined to the long …

Objective: SPG4 is an autosomal dominant pure form of hereditary spastic paraplegia (HSP)
caused by mutations in the SPAST gene. HSP is considered an upper motor neuron …

Hereditary spastic paraplegias (HSP) are a group of genetically and clinically
heterogeneous neurologic disorders. Hereby we describe a relatively large group of patients …

Background SPG11-linked hereditary spastic paraplegia is characterized by multisystem
neurodegeneration leading to a complex clinical and yet incurable phenotype of progressive …