The discovery of prions has challenged dogmas and has revolutionized our understanding
of protein‐misfolding diseases. The concept of self‐propagation via protein conformational …

Prion diseases are a group of neurodegenerative disorders associated with the
conformational conversion of the cellular prion protein (PrP C) into an abnormal misfolded …

Proteinopathies represent a group of diseases characterized by the unregulated misfolding
and aggregation of proteins. Accumulation of misfolded protein in the central nervous …

The term 'prion-like'is used to define some misfolded protein species that propagate
intercellularly, triggering protein aggregation in recipient cells. For cell binding, both direct …

The principal pathogenic event in Parkinson's disease is characterized by the
conformational change of α-synuclein, which form pathological aggregates of misfolded …

The misfolding and aggregation of specific proteins is a common hallmark of many
neurodegenerative disorders, including highly prevalent illnesses such as Alzheimer's and …

Specific protein misfolding and aggregation are mechanisms underlying various
neurodegenerative diseases such as prion disease and Alzheimer's disease (AD). The …

Prion disease research has contributed much toward understanding other
neurodegenerative diseases, including recent demonstrations that Alzheimer's disease (AD) …

Formation and aggregation of misfolded proteins in the central nervous system (CNS) is a
key hallmark of several age-related neurodegenerative diseases, including Parkinson's …

Protein intracellular inclusions within the central nervous system are hallmarks of several
progressive neurodegenerative disorders in man. The protein constituents of those deposits …