Despite the significant prevalence of Major Depressive Disorder in the pediatric population,
the pathophysiology of this condition remains unclear, and the treatment outcomes poor …

Depression is a leading cause of morbidity and mortality in youngsters. Elevated risk for the
disorder begins in the early teens and continues to rise in a linear fashion throughout …

Adolescent depression is an important global issue with several unmet needs that still must
be addressed and, to date, there are only few effective preventive strategies to reduce the …

Depression is a serious and persistent psychiatric disorder that commonly first manifests
during childhood. Depression that starts in childhood is increasing in frequency, likely due …

Aim: Paediatric major depressive disorder (MDD) is associated with chronicity and poor
outcomes. The goals of this review are (i) to integrate how developing biological systems …

Background While cytokines have been implicated in the pathophysiology of depression in
adults, the potential role in younger age groups such as adolescents is less clear. This …

Although there have been advances in our ability to treat child and adolescent depression,
use of evidence‐based treatments still results in many patients with residual symptoms …

Depression contributes greatly to global disability and is a leading cause of suicide. It has
multiple etiologies and therefore response to treatment can vary significantly. By applying …

Major depressive disorder (MDD) is a severe illness that afflicts about 16.6% of people over
their lifetime. MDD is highly correlated with suicidality, and often first presents in …

A plethora of research has implicated hundreds of putative biomarkers for depression, but
has not yet fully elucidated their roles in depressive illness or established what is abnormal …