The pathogenic role of angiotensin II (ANG II), dietary sodium chloride, sympathetic
activation, obesity and aldosterone in the development of structural vascular changes …

The elevated arterial pressure of chronic hypertension (HT) is caused by increased total
peripheral vascular resistance (TPVR). Hemodynamically, therefore, HT is the result of …

The rapid rise in the incidence and prevalence of obesity and the concomitant increase in
the incidence and prevalence of hypertension have fueled investigation into the role of …

In 1975 no one could have foreseen the colossal impact soon to be made on all areas of
medical research by molecular biology and genetics. The challenge now is to fit the new …

The dose and time dependence of angiotensin II (Ang II)–induced hypertension and
structural vascular changes and the effect of dietary sodium supplementation on these …

Elevated circulating angiotensin (Ang) II levels, dietary sodium, and sympathetic stimulation
are recurrent themes of hypertension research, but their in vivo interaction in physiologically …

The kidney plays a key role in the control of body fluids and blood pressure. Evidence has
shown that impairment of renal function can lead to the development of arterial …

Obesity is a major cause of human essential hypertension. Recent studies point toward
increased renal tubular reabsorption and abnormal renal pressure natriuresis in mediating …

In this review, we first summarize the evidence which indicates that the inability of the kidney
to excrete salt and water normally, particularly when combined with increased salt intake, is …

In the present work I focus on the pathophysiological mechanisms that may explain the
association between high sodium intake, obesity and high blood pressure. Despite …