Events mediated by the P-selectin/PSGL-1 pathway play a critical role in the initiation and
propagation of venous thrombosis by facilitating the accumulation of leukocytes and …

A plethora of data now supports an extensive overlap in the hemostatic and inflammatory
responses to tissue injury. Examples include disseminated intravascular coagulation during …

Introduction Platelet P-selectin is a thrombo-inflammatory molecule involved in platelet
activation and aggregation. This may occur via the adhesive function of P-selectin and its …

P-selectin and PSGL-1 are cell adhesion molecules, regulating the initial interactions
between leukocytes and the blood vessel wall as well as between activated platelets and …

We have previously shown that activated platelets in circulation stimulate release of
endothelial Weibel-Palade bodies thus increasing leukocyte rolling in venules. P-selectin on …

The platelet plays a pivotal role in maintaining vascular integrity. In a manner similar to
leukocytes, platelets interact with selectins expressed on activated endothelium. P-selectin …

Neutrophil P-selectin glycoprotein ligand-1 (PSGL-1) mediates the initial rolling and
adhesion of neutrophils to P-selectin on activated endothelium and platelets. Platelet …

INTRODUCTION: In thrombotic processes, during the association of leukocytes with
platelets and endothelial cells, P-selectin glycoprotein ligand-1 (PSGL-1) binds to P-selectin …

Endothelial and platelet P-selectin (CD62P) and leukocyte integrin αMβ2 (CD11bCD18,
Mac-1) are cell adhesion molecules essential for host defense and innate immunity. Upon …

Objective—The purpose of this study was to investigate the presence and functionality of P-
selectin glycoprotein ligand-1 (PSGL-1) on activated endothelial cells (ECs). Methods and …