Pharmacokinetics, pharmacodynamics, and therapeutic drug monitoring of valganciclovir and ganciclovir in transplantation

B Franck, J Autmizguine, P Marquet… - Clinical …, 2022 - Wiley Online Library
Ganciclovir and valganciclovir are first choice drugs for the prevention and treatment of
cytomegalovirus infection and disease in solid organ and stem cell transplant recipients …

Valganciclovir in adult solid organ transplant recipients: pharmacokinetic and pharmacodynamic characteristics and clinical interpretation of plasma concentration …

N Perrottet, LA Decosterd, P Meylan, M Pascual… - Clinical …, 2009 - Springer
Valganciclovir and ganciclovir are widely used for the prevention of cytomegalovirus (CMV)
infection in solid organ transplant recipients, with a major impact on patients' morbidity and …

Pharmacokinetic profile of ganciclovir after its oral administration and from its prodrug, valganciclovir, in solid organ transplant recipients

H Wiltshire, S Hirankarn, C Farrell, C Paya… - Clinical …, 2005 - Springer
Abstract Background Valganciclovir (Valcyte/sR) has recently been approved for the
prevention of cytomegalovirus (CMV) disease in high-risk (CMV donor positive [D+ …

Pharmacodynamics of oral ganciclovir and valganciclovir in solid organ transplant recipients

H Wiltshire, CV Paya, MD Pescovitz, A Humar… - …, 2005 - journals.lww.com
Background. A randomized, double-blind study was conducted to evaluate the
pharmacokinetics of ganciclovir following oral administration of ganciclovir or valganciclovir …

Optimization of Ganciclovir use in allogeneic hematopoietic cell transplant recipients–the role of therapeutic drug monitoring

SA Ho, M Slavin, JA Roberts, M Yong - Expert Review of Anti …, 2021 - Taylor & Francis
Introduction: Cytomegalovirus (CMV) is an opportunistic infectious complication that can
occur after allogeneic hematopoietic cell transplantation (HCT). The mainstay of treatment …

Population pharmacokinetics of ganciclovir in solid-organ transplant recipients receiving oral valganciclovir

N Perrottet, C Csajka, M Pascual… - Antimicrobial agents …, 2009 - Am Soc Microbiol
Valganciclovir (VGC) is an oral prodrug of ganciclovir (GCV) recently introduced for
prophylaxis and treatment of cytomegalovirus infection. Optimal concentration exposure for …

Variable viral clearance despite adequate ganciclovir plasma levels during valganciclovir treatment for cytomegalovirus disease in D+/R-transplant recipients

N Perrottet, O Manuel, F Lamoth, JP Venetz… - BMC infectious …, 2010 - Springer
Background Valganciclovir, the oral prodrug of ganciclovir, has been demonstrated
equivalent to iv ganciclovir for CMV disease treatment in solid organ transplant recipients …

Population pharmacokinetics of ganciclovir after valganciclovir treatment in children with renal transplant

A Facchin, V Elie, N Benyoub, S Magreault… - Antimicrobial Agents …, 2019 - Am Soc Microbiol
Valganciclovir, the ganciclovir prodrug, is an antiviral agent administered orally to prevent or
treat cytomegalovirus infection in solid-organ transplant recipients. The valganciclovir …

Ganciclovir pharmacokinetic parameters do not change when extending valganciclovir cytomegalovirus prophylaxis from 100 to 200 days

H Welker, M Farhan, A Humar, C Washington - Transplantation, 2010 - journals.lww.com
Background. A 3-month course of prophylaxis is usually recommended for cytomegalovirus
(CMV) D+/R− renal transplant recipients. Based on recent data, up to 6 months of …

Population pharmacokinetics of ganciclovir after intravenous ganciclovir and oral valganciclovir administration in solid organ transplant patients infected with …

A Caldés, H Colom, Y Armendariz… - Antimicrobial agents …, 2009 - Am Soc Microbiol
ABSTRACT A population pharmacokinetics analysis was performed after intravenous
ganciclovir and oral valganciclovir in solid organ transplant patients with cytomegalovirus …