Background Long-term cocaine exposure leads to dysregulation of the reward system and
initiates processes that ultimately weaken its rewarding effects. Here, we studied the …

Abstract Effects of stress on the reward system are well established in the literature.
Although previous studies have revealed that stress can reinstate extinguished addictive …

A goal in addiction research is to distinguish forms of neuroplasticity that are involved in the
transition to addiction from those involved in mere drug taking. Animal models of drug self …

Background Cocaine addiction is characterized by a progressive increase in drug intake
and a persistent craving for the drug during prolonged abstinence. Whether these two …

Heading Abstract Rationale. We have previously reported that pretreatment with the
corticosterone synthesis inhibitor ketoconazole blocks the electric foot-shock-induced …

Rationale The development of addiction is accompanied by a shift in the mechanisms
motivating cocaine use from nucleus accumbens (NAc) dopamine D 1 receptor (D 1 R) …

Pre‐clinical and clinical studies in cocaine addiction highlight alterations in the striatal
dopaminergic reward system that subserve maintenance of cocaine use. Using an …

Drug addiction is a chronic disease defined by a complex set of characteristics, including
loss of control over drug intake and persistent drug craving, which primarily affects a small …

Background The potential of abused drugs to induce addiction and compulsive drug-related
behavior is associated with their ability to alter dopamine signaling. Dopamine plays a key …

Women have a shorter course from initial cocaine use to meeting the criteria for cocaine use
disorder as compared to men. Preclinical findings similarly indicate that females develop key …