Regulatory circuitry governing fungal development, drug resistance, and disease
Pathogenic fungi have become a leading cause of human mortality due to the increasing
frequency of fungal infections in immunocompromised populations and the limited …
frequency of fungal infections in immunocompromised populations and the limited …
Molecular mechanisms governing antifungal drug resistance
Fungal pathogens are a severe public health problem. The leading causative agents of
systemic fungal infections include species from the Candida, Cryptococcus, and Aspergillus …
systemic fungal infections include species from the Candida, Cryptococcus, and Aspergillus …
Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulation
D Sanglard, A Coste, S Ferrari - FEMS yeast research, 2009 - academic.oup.com
Fungi are primitive eukaryotes and have adapted to a variety of niches during evolution.
Some fungal species may interact with other life forms (plants, insects, mammals), but are …
Some fungal species may interact with other life forms (plants, insects, mammals), but are …
Molecular evolution of antifungal drug resistance
The fungal pathogens Candida albicans, Cryptococcus neoformans, and Aspergillus
fumigatus have transitioned from a rare curiosity to a leading cause of human mortality. The …
fumigatus have transitioned from a rare curiosity to a leading cause of human mortality. The …
Antifungal therapy: new advances in the understanding and treatment of mycosis
L Scorzoni, ACA de Paula e Silva, CM Marcos… - Frontiers in …, 2017 - frontiersin.org
The high rates of morbidity and mortality caused by fungal infections are associated with the
current limited antifungal arsenal and the high toxicity of the compounds. Additionally …
current limited antifungal arsenal and the high toxicity of the compounds. Additionally …
Epigenetic mechanisms of drug resistance in fungi
The emergence of drug-resistant fungi poses a continuously increasing threat to human
health. Despite advances in preventive care and diagnostics, resistant fungi continue to …
health. Despite advances in preventive care and diagnostics, resistant fungi continue to …
Environmental Sensing and Signal Transduction Pathways Regulating Morphopathogenic Determinants of Candida albicans
Candida albicans is an opportunistic fungal pathogen that is found in the normal
gastrointestinal flora of most healthy humans. However, under certain environmental …
gastrointestinal flora of most healthy humans. However, under certain environmental …
[HTML][HTML] Facilitators of adaptation and antifungal resistance mechanisms in clinically relevant fungi
MWJ Hokken, BJ Zwaan, WJG Melchers… - Fungal genetics and …, 2019 - Elsevier
Opportunistic fungal pathogens can cause a diverse range of diseases in humans. The
increasing rate of fungal infections caused by strains that are resistant to commonly used …
increasing rate of fungal infections caused by strains that are resistant to commonly used …
Regulatory mechanisms controlling morphology and pathogenesis in Candida albicans
D Kadosh - Current opinion in microbiology, 2019 - Elsevier
Highlights•There is a strong association between C. albicans morphology and virulence.•C.
albicans morphology control mechanisms may serve as important antifungal …
albicans morphology control mechanisms may serve as important antifungal …
Master and commander in fungal pathogens: the two-component system and the HOG signaling pathway
YS Bahn - Eukaryotic cell, 2008 - Am Soc Microbiol
All living organisms, whether they be single-or multicellular, actively interact with their
surrounding environments and modulate their physiological status to maintain cellular …
surrounding environments and modulate their physiological status to maintain cellular …