The food and drug addiction epidemic: targeting dopamine homeostasis

K Blum, PK Thanos, GJ Wang, M Febo… - Current …, 2017 - ingentaconnect.com
Obesity is damaging the lives of more than 300 million people worldwide and maintaining a
healthy weight using popular weight loss tactics remains a very difficult undertaking …

[HTML][HTML] Could dopamine agonists aid in drug development for anorexia nervosa?

GKW Frank - Frontiers in nutrition, 2014 - frontiersin.org
Anorexia nervosa is a severe psychiatric disorder most commonly starting during the
teenage-years and associated with food refusal and low body weight. Typically there is a …

The dopamine motive system: implications for drug and food addiction

ND Volkow, RA Wise, R Baler - Nature Reviews Neuroscience, 2017 - nature.com
Behaviours such as eating, copulating, defending oneself or taking addictive drugs begin
with a motivation to initiate the behaviour. Both this motivational drive and the behaviours …

You are what you eat: influence of type and amount of food consumed on central dopamine systems and the behavioral effects of direct-and indirect-acting dopamine …

MG Baladi, LC Daws, CP France - Neuropharmacology, 2012 - Elsevier
The important role of dopamine (DA) in mediating feeding behavior and the positive
reinforcing effects of some drugs is well recognized. Less widely studied is how feeding …

Dopamine and diet-induced obesity

AG DiFeliceantonio, DM Small - Nature Neuroscience, 2019 - nature.com
In 2010, Johnson and Kenny provided conclusive evidence that extended access to a
Western-style diet promotes addictive-like behavior in rats by downregulating D2 receptors …

A shared molecular and genetic basis for food and drug addiction: overcoming hypodopaminergic trait/state by incorporating dopamine agonistic therapy in psychiatry

MS Gold, RD Badgaiyan, K Blum - Psychiatric Clinics, 2015 - psych.theclinics.com
How we feel when we are starving or miss a meal, or two, may be linked to the brain's
complex role in controlling appetite. This understanding may be crucial in efforts to develop …

[HTML][HTML] Striatal dopamine links gastrointestinal rerouting to altered sweet appetite

W Han, LA Tellez, J Niu, S Medina, TL Ferreira… - Cell metabolism, 2016 - cell.com
Reductions in calorie intake contribute significantly to the positive outcome of bariatric
surgeries. However, the physiological mechanisms linking the rerouting of the …

Pharmacological interventions for obesity: current and future targets

ME Bocarsly - Current addiction reports, 2018 - Springer
Abstract Purpose of Review Obesity in the USA has been on a constant rise since the Center
for Disease Control and Prevention (CDC) began tracking it over 50 years ago. Despite …

[HTML][HTML] Dopamine signaling in food addiction: role of dopamine D2 receptors

JH Baik - BMB reports, 2013 - ncbi.nlm.nih.gov
Dopamine (DA) regulates emotional and motivational behavior through the mesolimbic
dopaminergic pathway. Changes in DA signaling in mesolimbic neurotransmission are …

Mesolimbic dopamine and its neuromodulators in obesity and binge eating

L Naef, KA Pitman, SL Borgland - CNS spectrums, 2015 - cambridge.org
Obesity has reached epidemic prevalence, and much research has focused on homeostatic
and nonhomeostatic mechanisms underlying overconsumption of food. Mesocorticolimbic …