Maintenance of genome stability requires control over the expression of transposable
elements (TEs), whose activity can have substantial deleterious effects on the host …

Transposable elements dominate the mammalian genome, but their contribution to genetic
and epigenetic regulation has been largely overlooked. This was in part due to technical …

Multicellular eukaryotic genomes show enormous differences in size. A substantial part of
this variation is due to the presence of transposable elements (TEs). They contribute …

Transposable elements (TEs) comprise a group of repetitive sequences that bring positive,
negative, as well as neutral effects to the host organism. Earlier considered as “junk DNA,” …

Chemical modification of nucleotide bases in DNA provides one mechanism for conveying
information in addition to the genetic code. 5-methylcytosine (5mC) represents the most …

The DNA-adenine modification N 6-methyladenine (6mA), initially thought to be mainly
restricted to prokaryotes and certain unicellular eukaryotes, has recently been found in …

DNA modifications are used to regulate gene expression and defend against invading
genetic elements. In eukaryotes, modifications predominantly involve C5-methylcytosine …

Demethylation of 5-methylcytosine in DNA is integral to the maintenance of an intact
epigenome. The balance between the presence or absence of 5-methylcytosine determines …

DNA methylation has a profound impact on genome stability, transcription and development.
Although enzymes that catalyse DNA methylation have been well characterized, those that …

Overlapping epigenetic mechanisms have evolved in eukaryotic cells to silence the
expression and mobility of transposable elements (TEs). Owing to their ability to recruit the …