Protective responses to microorganisms involve the nonspecific but rapid defence
mechanisms of the innate immune system, followed by the specific but slow defence …

Marginal zone (MZ) B cells, together with other strategically located innate cells, constitute
the first line of defense against blood-borne microorganisms, viruses and toxins in the …

It is now clear that functionally distinct subsets of mature peripheral B cells exist. Of these
subsets, marginal zone (MZ) B cells in the spleen are strategically positioned at the blood …

To maintain the integrity of an organism constantly challenged by pathogens, the immune
system is endowed with a variety of cell types. B lymphocytes were initially thought to only …

Marginal zone (MZ) B cells comprise a subset of innate-like B cells found predominantly in
the spleen, but also in lymph nodes and blood. Their principal functions are participation in …

The rate of pathogen elimination determines the extent and consequences of an infection. In
this context, the spleen with its highly specialized lymphoid compartments plays a central …

Marginal zone (MZ) and B1 B lymphocytes participate jointly in the early immune response
against T-independent (TI) particulate antigens. Here we show that blood-derived neutrophil …

▪ Abstract Our views regarding the origins and functions of splenic marginal zone B cells
have changed considerably over the past few years. Perspectives regarding the …

Having evolved to generate a huge Ag-specific repertoire and to mount T cell-dependent
responses and long-term memory, the B lymphocyte is a central player in the adaptive …

Innate lymphoid cells (ILCs) regulate stromal cells, epithelial cells and cells of the immune
system, but their effect on B cells remains unclear. Here we identified RORγt+ ILCs near the …