mTOR: from growth signal integration to cancer, diabetes and ageing
R Zoncu, A Efeyan, DM Sabatini - Nature reviews Molecular cell biology, 2011 - nature.com
In all eukaryotes, the target of rapamycin (TOR) signalling pathway couples energy and
nutrient abundance to the execution of cell growth and division, owing to the ability of TOR …
nutrient abundance to the execution of cell growth and division, owing to the ability of TOR …
mTOR-dependent cell survival mechanisms
CM Hung, L Garcia-Haro… - Cold Spring Harbor …, 2012 - cshperspectives.cshlp.org
The mechanistic target of rapamycin (mTOR) kinase is a conserved regulator of cell growth,
proliferation, and survival. In cells, mTOR is the catalytic subunit of two complexes called …
proliferation, and survival. In cells, mTOR is the catalytic subunit of two complexes called …
mTOR in aging, metabolism, and cancer
M Cornu, V Albert, MN Hall - Current opinion in genetics & development, 2013 - Elsevier
The target of rapamycin (TOR) is a highly conserved serine/threonine kinase that is part of
two structurally and functionally distinct complexes, TORC1 and TORC2. In multicellular …
two structurally and functionally distinct complexes, TORC1 and TORC2. In multicellular …
Regulation of mTORC1 by upstream stimuli
CH Melick, JL Jewell - Genes, 2020 - mdpi.com
The mammalian target of rapamycin (mTOR) is an evolutionary conserved Ser/Thr protein
kinase that senses multiple upstream stimuli to control cell growth, metabolism, and …
kinase that senses multiple upstream stimuli to control cell growth, metabolism, and …
mTOR complex 2 signaling and functions
WJ Oh, E Jacinto - Cell cycle, 2011 - Taylor & Francis
The mechanistic target of rapamycin (mTOR) plays a central role in cellular growth and
metabolism. mTOR forms two distinct protein complexes, mTORC1 and mTORC2. Much is …
metabolism. mTOR forms two distinct protein complexes, mTORC1 and mTORC2. Much is …
mTOR signaling in disease
E Dazert, MN Hall - Current opinion in cell biology, 2011 - Elsevier
The target of rapamycin (TOR) is a highly conserved serine/threonine kinase and a central
controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in …
controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in …
Weighing in on mTOR complex 2 signaling: the expanding role in cell metabolism
Y Luo, W Xu, G Li, W Cui - Oxidative medicine and cellular …, 2018 - Wiley Online Library
In all eukaryotes, the mechanistic target of rapamycin (mTOR) signaling emerges as a
master regulator of homeostasis, which integrates environmental inputs, including nutrients …
master regulator of homeostasis, which integrates environmental inputs, including nutrients …
Regulation of mTORC1 and its impact on gene expression at a glance
M Laplante, DM Sabatini - Journal of cell science, 2013 - journals.biologists.com
The mechanistic (or mammalian) target of rapamycin (mTOR) is a kinase that regulates key
cellular functions linked to the promotion of cell growth and metabolism. This kinase, which …
cellular functions linked to the promotion of cell growth and metabolism. This kinase, which …
mTOR links oncogenic signaling to tumor cell metabolism
JL Yecies, BD Manning - Journal of molecular medicine, 2011 - Springer
As a key regulator of cell growth and proliferation, the mammalian target of rapamycin
(mTOR) complex 1 (mTORC1) has been the subject of intense investigation for its role in …
(mTOR) complex 1 (mTORC1) has been the subject of intense investigation for its role in …
mTOR signaling in growth, metabolism, and disease
RA Saxton, DM Sabatini - Cell, 2017 - cell.com
The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and
metabolism with environmental inputs, including nutrients and growth factors. Extensive …
metabolism with environmental inputs, including nutrients and growth factors. Extensive …