A drawback of extensive coxib use for antitumor purposes is the risk of life-threatening side
effects that are thought to be a class effect and probably due to the resulting imbalance of …

Background An increasing number of reports is challenging the notion that the antitumor
potential of the selective COX-2 inhibitor celecoxib (Celebrex®) is mediated primarily via the …

Celecoxib is a paradigmatic selective inhibitor of cyclooxygenase-2 (COX-2). This anti-
inflammatory drug has potent anti-tumor activity in a wide variety of human epithelial tumor …

✓ Celecoxib (Celebrex) appears to be unique among the class of selective COX-2 inhibitors
(coxibs), because this particular compound exerts a second function that is independent of …

The non-steroidal anti-inflammatory drug (NSAID) celecoxib is a selective cyclooxygenase-2
(COX-2) inhibitor that has shown some promising results as an anti-cancer drug. However …

Celecoxib, a COX-2 (cyclooxygenase-2)-selective inhibitor (coxib), is the only NSAID (non-
steroidal anti-inflammatory drug) that has been approved for adjuvant treatment of patients …

Celecoxib is a potent nonsteroid antiinflammatory drug (NSAID) that has shown great
promise in cancer chemoprevention and treatment. The tumor suppression activity of …

The proteasome inhibitor bortezomib (Velcade) is known to trigger endoplasmic reticulum
(ER) stress via the accumulation of obsolete and damaged proteins. The selective …

2, 5-dimethyl-celecoxib (DMC) is a close structural analog of the selective cyclooxygenase-2
(COX-2) inhibitor celecoxib that lacks COX-2 inhibitory function. We and others have …

Moderate activity of the endoplasmic reticulum (ER) stress response system exerts anti-
apoptotic function and supports tumor cell survival and chemoresistance, whereas its more …