Transgenic mouse models of Aβ amyloidosis generated by knock-in of a humanized Aβ
sequence can offer some advantages over the transgenic models that overexpress amyloid …

The recent development of knock-in mouse models of Alzheimer's disease provides distinct
advantages over traditional transgenic mouse models that rely on over-expression of …

Background Alzheimer's disease (AD), the most common cause of dementia, is
characterized by the progressive deposition of amyloid-β (Aβ) peptides and neurofibrillary …

Saito et al developed a novel amyloid precursor protein (APP) knock-in mouse model (APP
NL-GF) for Alzheimer's disease (AD) to overcome the problem of overexpression of APP in …

In the last decade, multiple lines of transgenic APP overexpressing mice have been created
that recapitulate certain aspects of Alzheimer's disease (AD). However, none of the …

Numerous transgenic mouse models for Alzheimer's disease (AD) have been generated to
recapitulate the histological pathogenesis and behavioral phenotypes of AD brain. However …

Transgenic mouse models of Alzheimer's disease (AD) with nonphysiologic overexpression
of amyloid precursor protein (APP) exhibit various unnatural symptoms/dysfunctions. To …

Alzheimer's disease (AD) is characterized by increased β amyloid (Aβ) levels, extracellular
Aβ deposits in senile plaques, neurofibrillary tangles, and neuronal loss. However, the …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive
decline and amyloid-beta (Aβ) depositions generated by the proteolysis of amyloid …

Transgenic mice expressing mutant amyloid precursor proteins (APPs) have provided
important new information about the pathogenesis of Alzheimer's disease (AD) …