The fibrogenic niche in kidney fibrosis: components and mechanisms

L Li, H Fu, Y Liu - Nature Reviews Nephrology, 2022 - nature.com
Kidney fibrosis, characterized by excessive deposition of extracellular matrix (ECM) that
leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney …

[HTML][HTML] Defining therapeutic targets for renal fibrosis: Exploiting the biology of pathogenesis

H Yan, J Xu, Z Xu, B Yang, P Luo, Q He - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Renal fibrosis is a failed wound-healing process of the kidney tissue after chronic, sustained
injury, which is a common pathway and pathological marker of virtually every type of chronic …

Kidney fibrosis: from mechanisms to therapeutic medicines

R Huang, P Fu, L Ma - Signal Transduction and Targeted Therapy, 2023 - nature.com
Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

Cellular and molecular mechanisms of kidney fibrosis

S Djudjaj, P Boor - Molecular aspects of medicine, 2019 - Elsevier
Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …

The origin of renal fibroblasts/myofibroblasts and the signals that trigger fibrosis

YBY Sun, X Qu, G Caruana, J Li - Differentiation, 2016 - Elsevier
Renal fibrosis is a common characteristic of chronic kidney disease (CKD). Aberrant and
excessive depositions of extracellular matrix (ECM) proteins in both glomeruli and interstitial …

What can target kidney fibrosis?

IA Leaf, JS Duffield - Nephrology Dialysis Transplantation, 2017 - academic.oup.com
Fibrosis, a characteristic of all chronic kidney diseases, is now recognized to be an
independent predictor of disease progression. Deposition of pathological matrix in the walls …

Extracellular matrix in kidney fibrosis: more than just a scaffold

RD Bülow, P Boor - Journal of Histochemistry & …, 2019 - journals.sagepub.com
Kidney fibrosis is the common histological end-point of progressive, chronic kidney diseases
(CKDs) regardless of the underlying etiology. The hallmark of renal fibrosis, similar to all …

Renal fibrosis: novel insights into mechanisms and therapeutic targets

P Boor, T Ostendorf, J Floege - Nature Reviews Nephrology, 2010 - nature.com
Renal fibrosis is the common end point of virtually all progressive kidney diseases. Renal
fibrosis should not be viewed as a simple and uniform'scar', but rather as a dynamic system …

Cellular and molecular mechanisms in kidney fibrosis

JS Duffield - The Journal of clinical investigation, 2014 - Am Soc Clin Investig
Fibrosis is a characteristic feature of all forms of chronic kidney disease. Deposition of
pathological matrix in the interstitial space and within the walls of glomerular capillaries as …

Interplay between extracellular matrix components and cellular and molecular mechanisms in kidney fibrosis

S Rayego-Mateos, S Campillo… - Clinical …, 2021 - portlandpress.com
Chronic kidney disease (CKD) is characterized by pathological accumulation of extracellular
matrix (ECM) proteins in renal structures. Tubulointerstitial fibrosis is observed in glomerular …