There is a lack of techniques for noninvasive imaging of pulmonary inflammation associated
with acute lung injury and pulmonary fibrosis. Here we determined the potential of positron …

The lack of techniques for noninvasive imaging of inflammation has challenged precision
medicine management of acute respiratory distress syndrome (ARDS). Here, we determined …

Precision management of fibrotic lung diseases is challenging due to their diverse clinical
trajectories and lack of reliable biomarkers for risk stratification and therapeutic monitoring …

Purpose To characterize a chemokine receptor type 2 (CCR2)–binding peptide adapted for
use as a positron emission tomography (PET) radiotracer for noninvasive detection of lung …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a progressive inflammatory lung disease
without effective molecular markers of disease activity or treatment responses. Monocyte …

Pulmonary fibrosis (PF) is a debilitating interstitial lung disease with few treatment options.
The pathogenesis of idiopathic PF likely involves recurring microinjuries to the alveolar …

Purpose Among different chemokines, monocyte chemoattractant protein-1 (MCP-1) plays
an important role in inflammatory disorders of lung. In response to stimuli, MCP-1 increases …

Lung CCR2+(Chemokine receptor 2) inflammatory monocytes are elevated in the lungs of
patients with pulmonary fibrosis and in preclinical models of lung fibrosis. Genetic depletion …

Imaging techniques for detection of molecular and cellular processes that precede or
accompany lung diseases are needed. Matrix metalloproteinases (MMPs) play key roles in …

CC chemokine ligand-2 (CCL2)/monocyte chemoattractant protein (MCP)-1 expression is
upregulated during pulmonary inflammation, and the CCL2-CCR2 axis plays a critical role in …