Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses
Summary CD4 T follicular helper (TFH) cells support B cells, which are critical for germinal
center (GC) formation, but the importance of TFH-B cell interactions in cancer is unclear. We …
center (GC) formation, but the importance of TFH-B cell interactions in cancer is unclear. We …
[HTML][HTML] Follicular helper-T cells restore CD8+-dependent antitumor immunity and anti-PD-L1/PD-1 efficacy
J Niogret, H Berger, C Rebe, R Mary… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background T follicular helper cells (Tfh) are essential to shape B cell response during
germinal center formation. Tfh accumulation has been reported in various human cancers …
germinal center formation. Tfh accumulation has been reported in various human cancers …
T follicular helper cells in cancer
N Gutiérrez-Melo, D Baumjohann - Trends in cancer, 2023 - cell.com
T follicular helper (Tfh) cells provide essential help to B cells for effective antibody-mediated
immune responses. Although the crucial function of these CD4+ T cells in infection and …
immune responses. Although the crucial function of these CD4+ T cells in infection and …
Direct tumor recognition by a human CD4+ T-cell subset potently mediates tumor growth inhibition and orchestrates anti-tumor immune responses
J Matsuzaki, T Tsuji, IF Luescher, H Shiku, J Mineno… - Scientific reports, 2015 - nature.com
Tumor antigen-specific CD4+ T cells generally orchestrate and regulate immune cells to
provide immune surveillance against malignancy. However, activation of antigen-specific …
provide immune surveillance against malignancy. However, activation of antigen-specific …
Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors
CD8 T cell responses against different tumor neoantigens occur simultaneously, yet little is
known about the interplay between responses and its impact on T cell function and tumor …
known about the interplay between responses and its impact on T cell function and tumor …
A reservoir of stem-like CD8+ T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response
“Stem-like” TCF1+ CD8+ T (TSL) cells are necessary for long-term maintenance of T cell
responses and the efficacy of immunotherapy, but, as tumors contain signals that should …
responses and the efficacy of immunotherapy, but, as tumors contain signals that should …
Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors
J Schmidt, J Chiffelle, MAS Perez, M Magnin… - Nature …, 2023 - nature.com
The success of cancer immunotherapy depends in part on the strength of antigen
recognition by T cells. Here, we characterize the T cell receptor (TCR) functional (antigen …
recognition by T cells. Here, we characterize the T cell receptor (TCR) functional (antigen …
Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors
SE Brightman, A Becker, RR Thota, MS Naradikian… - Nature …, 2023 - nature.com
CD4+ T cells play key roles in a range of immune responses, either as direct effectors or
through accessory cells, including CD8+ T lymphocytes. In cancer, neoantigen (NeoAg) …
through accessory cells, including CD8+ T lymphocytes. In cancer, neoantigen (NeoAg) …
CD8 T cell help for innate antitumor immunity
Innate immunity is considered to initiate adaptive antitumor responses. We demonstrate that
monoclonal CD8 T lymphocytes reactive to tumor Ag P1A on P815 mastocytoma cells …
monoclonal CD8 T lymphocytes reactive to tumor Ag P1A on P815 mastocytoma cells …
CD8+ T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor
N Prokhnevska, MA Cardenas, RM Valanparambil… - Immunity, 2023 - cell.com
Improvements in tumor immunotherapies depend on better understanding of the anti-tumor
T cell response. By studying human tumor-draining lymph nodes (TDLNs), we found that …
T cell response. By studying human tumor-draining lymph nodes (TDLNs), we found that …