Advancing precision medicine therapeutics for Parkinson's utilizing a shared quantitative systems pharmacology model and framework
C Denaro, D Stephenson, MLTM Müller… - Frontiers in Systems …, 2024 - frontiersin.org
A rich pipeline of therapeutic candidates is advancing for Parkinson's disease, many of
which are targeting the underlying pathophysiology of disease. Emerging evidence …
which are targeting the underlying pathophysiology of disease. Emerging evidence …
Computational systems biology approaches for Parkinson's disease
E Glaab - Cell and tissue research, 2018 - Springer
Parkinson's disease (PD) is a prime example of a complex and heterogeneous disorder,
characterized by multifaceted and varied motor-and non-motor symptoms and different …
characterized by multifaceted and varied motor-and non-motor symptoms and different …
Role of rodent models in advancing precision medicine for Parkinson's disease
E Simons, SM Fleming - Handbook of clinical neurology, 2023 - Elsevier
With a current lack of disease-modifying treatments, an initiative toward implementing a
precision medicine approach for treating Parkinson's disease (PD) has emerged. However …
precision medicine approach for treating Parkinson's disease (PD) has emerged. However …
Rational drug discovery design approaches for treating Parkinson's disease
CJ Van der Schyf - Expert opinion on drug discovery, 2015 - Taylor & Francis
Introduction: Parkinson's disease (PD) is a severe progressive neurodegenerative disorder.
As yet, no therapeutic agent can prevent the characteristic neuronal cell loss in PD brain …
As yet, no therapeutic agent can prevent the characteristic neuronal cell loss in PD brain …
[HTML][HTML] Progress toward an integrated understanding of Parkinson's disease
MWC Rousseaux, JM Shulman, J Jankovic - F1000Research, 2017 - ncbi.nlm.nih.gov
Parkinson's disease (PD) is the second most common neurodegenerative disorder after
Alzheimer's disease, affecting over 10 million individuals worldwide. While numerous …
Alzheimer's disease, affecting over 10 million individuals worldwide. While numerous …
Repositioning drugs by targeting network modules: a Parkinson's disease case study
Background Much effort has been devoted to the discovery of specific mechanisms between
drugs and single targets to date. However, as biological systems maintain homeostasis at …
drugs and single targets to date. However, as biological systems maintain homeostasis at …
Bioinformatics approaches for parkinson's disease in clinical practice: Data-driven biomarkers and pharmacological treatment
Parkinson's disease is a gradually progressive neurodegenerative disorder characterized by
a selective loss of dopaminergic neurons in the midbrain area called the substantia nigra …
a selective loss of dopaminergic neurons in the midbrain area called the substantia nigra …
Emerging perspectives Perspectives on precision Precision therapy Therapy for Parkinson's Disease: Multidimensional Evidence Leading to a New Breakthrough in …
Q Wang, L Yang, Y Jiang, J Zhang, J He - Frontiers in Aging Neuroscience - frontiersin.org
PD is a prevalent and progressive neurodegenerative disorder characterized by both motor
and non-motor symptoms. Genes play a significant role in the onset and progression of the …
and non-motor symptoms. Genes play a significant role in the onset and progression of the …
Precision medicine in Parkinson's disease: from genetic risk signals to personalized therapy
G Straccia, F Colucci, R Eleopra, R Cilia - Brain Sciences, 2022 - mdpi.com
Understanding the pathophysiology and genetic background of Parkinson's disease (PD)
increases the likelihood of developing effective disease-modifying therapeutic strategies. In …
increases the likelihood of developing effective disease-modifying therapeutic strategies. In …
Cohort-specific Boolean models highlight different regulatory modules during Parkinson's disease progression
Parkinson's Disease (PD) is a multifaceted neurodegenerative disorder characterised by
complex molecular dysregulations and diverse comorbidities. It is critical to decode the …
complex molecular dysregulations and diverse comorbidities. It is critical to decode the …