Advancing precision medicine therapeutics for Parkinson's utilizing a shared quantitative systems pharmacology model and framework

C Denaro, D Stephenson, MLTM Müller… - Frontiers in Systems …, 2024 - frontiersin.org
A rich pipeline of therapeutic candidates is advancing for Parkinson's disease, many of
which are targeting the underlying pathophysiology of disease. Emerging evidence …

Computational systems biology approaches for Parkinson's disease

E Glaab - Cell and tissue research, 2018 - Springer
Parkinson's disease (PD) is a prime example of a complex and heterogeneous disorder,
characterized by multifaceted and varied motor-and non-motor symptoms and different …

Role of rodent models in advancing precision medicine for Parkinson's disease

E Simons, SM Fleming - Handbook of clinical neurology, 2023 - Elsevier
With a current lack of disease-modifying treatments, an initiative toward implementing a
precision medicine approach for treating Parkinson's disease (PD) has emerged. However …

Rational drug discovery design approaches for treating Parkinson's disease

CJ Van der Schyf - Expert opinion on drug discovery, 2015 - Taylor & Francis
Introduction: Parkinson's disease (PD) is a severe progressive neurodegenerative disorder.
As yet, no therapeutic agent can prevent the characteristic neuronal cell loss in PD brain …

[HTML][HTML] Progress toward an integrated understanding of Parkinson's disease

MWC Rousseaux, JM Shulman, J Jankovic - F1000Research, 2017 - ncbi.nlm.nih.gov
Parkinson's disease (PD) is the second most common neurodegenerative disorder after
Alzheimer's disease, affecting over 10 million individuals worldwide. While numerous …

Repositioning drugs by targeting network modules: a Parkinson's disease case study

Z Yue, I Arora, EY Zhang, V Laufer, SL Bridges… - BMC …, 2017 - Springer
Background Much effort has been devoted to the discovery of specific mechanisms between
drugs and single targets to date. However, as biological systems maintain homeostasis at …

Bioinformatics approaches for parkinson's disease in clinical practice: Data-driven biomarkers and pharmacological treatment

MG Krokidis, T Exarchos, P Vlamos - GeNeDis 2020: Computational …, 2021 - Springer
Parkinson's disease is a gradually progressive neurodegenerative disorder characterized by
a selective loss of dopaminergic neurons in the midbrain area called the substantia nigra …

Emerging perspectives Perspectives on precision Precision therapy Therapy for Parkinson's Disease: Multidimensional Evidence Leading to a New Breakthrough in …

Q Wang, L Yang, Y Jiang, J Zhang, J He - Frontiers in Aging Neuroscience - frontiersin.org
PD is a prevalent and progressive neurodegenerative disorder characterized by both motor
and non-motor symptoms. Genes play a significant role in the onset and progression of the …

Precision medicine in Parkinson's disease: from genetic risk signals to personalized therapy

G Straccia, F Colucci, R Eleopra, R Cilia - Brain Sciences, 2022 - mdpi.com
Understanding the pathophysiology and genetic background of Parkinson's disease (PD)
increases the likelihood of developing effective disease-modifying therapeutic strategies. In …

Cohort-specific Boolean models highlight different regulatory modules during Parkinson's disease progression

AA Hemedan, VP Satagopam, R Schneider… - bioRxiv, 2024 - biorxiv.org
Parkinson's Disease (PD) is a multifaceted neurodegenerative disorder characterised by
complex molecular dysregulations and diverse comorbidities. It is critical to decode the …