Purinergic signalling appears to play important roles in neurodegeneration, neuroprotection
and neuroregeneration. Initially there is a brief summary of the background of purinergic …

Ischemia is a multifactorial pathology characterized by different events evolving in the time.
After ischemia a primary damage due to the early massive increase of extracellular …

Purinergic signaling modulates dopaminergic neurotransmission in health and disease.
Classically adenosine A 1 and A 2A receptors have been considered key for the fine tune …

Abstract ATP (adenosine 5′-triphosphate), one of the most ancient neurotransmitters,
exerts essential functions in the brain, including neurotransmission and modulation of …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive
loss of memory and cognitive ability and is a serious cause of mortality. Many of the …

Purines have key roles in neurotransmission and neuromodulation, with their effects being
mediated by the purine and pyrimidine receptor subfamilies, P1, P2X and P2Y. Recently …

Purinergic signalling, ie ATP as an extracellular signalling molecule and cotransmitter in
both peripheral and central neurons, is involved in the physiology of neurotransmission and …

The emphasis in this article is on the growing interest in the pathophysiology and
therapeutic potential of purinergic signalling. 1–8 However, it begins with a review of the …

Purinergic neurotransmission, involving release of ATP as an efferent neurotransmitter was
first proposed in 1972. Later, ATP was recognised as a cotransmitter in peripheral nerves …

Some areas of current interest in the rapidly expanding purinergic signalling field that are
controversial or are unresolved are highlighted in this review. These include the …