Co-exposure to polystyrene microplastics and di-(2-ethylhexyl) phthalate aggravates allergic asthma through the TRPA1-p38 MAPK pathway

Q Han, X Gao, S Wang, Z Wei, Y Wang, K Xu, M Chen - Toxicology Letters, 2023 - Elsevier
Increasing attention has been paid to the potential impact of microplastics (MPs) pollution on
human health. MPs and phthalates coexist in the environment, however, the effects of …

Detrimental effects of microplastic exposure on normal and asthmatic pulmonary physiology

K Lu, KP Lai, T Stoeger, S Ji, Z Lin, X Lin… - Journal of hazardous …, 2021 - Elsevier
Concerns that airborne microplastics (MP) may be detrimental to human health are rising.
However, research on the effects of MP on the respiratory system are limited. We tested the …

Mono-2-ethylhexylphthalate (MEHP) induces TNF-α release and macrophage differentiation through different signalling pathways in RAW264. 7 cells

AK Bølling, J Ovrevik, JT Samuelsen, JA Holme… - Toxicology letters, 2012 - Elsevier
Epidemiological studies have associated indoor phthalate exposure with increased
incidences and severity of asthma in children and adults, and inflammatory effects have …

Polystyrene microplastic particles: In vitro pulmonary toxicity assessment

CD Dong, CW Chen, YC Chen, HH Chen… - Journal of hazardous …, 2020 - Elsevier
Microplastics (MPs) have become a global environmental concern. Recent studies have
shown that MPs, of which the predominant type is often polystyrene (PS; known as PS-MPs) …

Mono (2-ethylhexyl) phthalate induces both pro-and anti-inflammatory responses in rat alveolar macrophages through crosstalk between p38, the lipoxygenase …

KE Rakkestad, JA Holme, RE Paulsen… - Inhalation …, 2010 - Taylor & Francis
Airway inflammation is important in asthma pathogenesis. Recent epidemiological data
have indicated an association between asthma symptoms in children and exposure to di (2 …

Exposure to diisodecyl phthalate exacerbated Th2 and Th17-mediated asthma through aggravating oxidative stress and the activation of p38 MAPK

W Qin, T Deng, H Cui, Q Zhang, X Liu, X Yang… - Food and Chemical …, 2018 - Elsevier
Diisodecyl phthalate (DIDP) is considered to be one of the less toxic phthalates. However
epidemiological studies suggest that DIDP is associated with the occurrence of asthma. The …

Cellular response of THP-1 macrophages to polystyrene microplastics exposure

S Koner, I Florance, A Mukherjee, N Chandrasekaran - Toxicology, 2023 - Elsevier
Microplastic in the environment have the capability to reach the human immune system via
the ingestion, inhalation and direct contact. Polystyrene (PS) is one of the most widely used …

Dibutyl phthalate aggravated asthma-like symptoms through oxidative stress and increasing calcitonin gene-related peptide release

S Zhou, M Han, Y Ren, X Yang, L Duan, Y Zeng… - … and Environmental Safety, 2020 - Elsevier
Dibutyl phthalate (DBP) is one of the most ubiquitous phthalate esters found in everyday
products, and is receiving increased attention as an immunologic adjuvant. However …

Mediation of endoplasmic reticulum stress and NF-κB signaling pathway in DINP-exacerbated allergic asthma: A toxicological study with Balb/c mice

F Lei, Y Wu, C Li, B Yan, S Chen, Q Peng… - Journal of Hazardous …, 2023 - Elsevier
Epidemiological evidence indicates a significant relationship between exposure to
diisononyl phthalate and allergic asthma. Despite this, the mechanism underlying this …

Polystyrene microplastic particles induce autophagic cell death in BEAS‐2B human bronchial epithelial cells

MS Jeon, JW Kim, YB Han, MH Jeong… - Environmental …, 2023 - Wiley Online Library
The detection of high levels of microplastics in indoor and outdoor air has increased
concerns regarding its toxic effects on the respiratory system. They are not easily …