Co-exposure to polystyrene microplastics and di-(2-ethylhexyl) phthalate aggravates allergic asthma through the TRPA1-p38 MAPK pathway
Q Han, X Gao, S Wang, Z Wei, Y Wang, K Xu, M Chen - Toxicology Letters, 2023 - Elsevier
Increasing attention has been paid to the potential impact of microplastics (MPs) pollution on
human health. MPs and phthalates coexist in the environment, however, the effects of …
human health. MPs and phthalates coexist in the environment, however, the effects of …
Detrimental effects of microplastic exposure on normal and asthmatic pulmonary physiology
Concerns that airborne microplastics (MP) may be detrimental to human health are rising.
However, research on the effects of MP on the respiratory system are limited. We tested the …
However, research on the effects of MP on the respiratory system are limited. We tested the …
Mono-2-ethylhexylphthalate (MEHP) induces TNF-α release and macrophage differentiation through different signalling pathways in RAW264. 7 cells
Epidemiological studies have associated indoor phthalate exposure with increased
incidences and severity of asthma in children and adults, and inflammatory effects have …
incidences and severity of asthma in children and adults, and inflammatory effects have …
Polystyrene microplastic particles: In vitro pulmonary toxicity assessment
CD Dong, CW Chen, YC Chen, HH Chen… - Journal of hazardous …, 2020 - Elsevier
Microplastics (MPs) have become a global environmental concern. Recent studies have
shown that MPs, of which the predominant type is often polystyrene (PS; known as PS-MPs) …
shown that MPs, of which the predominant type is often polystyrene (PS; known as PS-MPs) …
Mono (2-ethylhexyl) phthalate induces both pro-and anti-inflammatory responses in rat alveolar macrophages through crosstalk between p38, the lipoxygenase …
KE Rakkestad, JA Holme, RE Paulsen… - Inhalation …, 2010 - Taylor & Francis
Airway inflammation is important in asthma pathogenesis. Recent epidemiological data
have indicated an association between asthma symptoms in children and exposure to di (2 …
have indicated an association between asthma symptoms in children and exposure to di (2 …
Exposure to diisodecyl phthalate exacerbated Th2 and Th17-mediated asthma through aggravating oxidative stress and the activation of p38 MAPK
Diisodecyl phthalate (DIDP) is considered to be one of the less toxic phthalates. However
epidemiological studies suggest that DIDP is associated with the occurrence of asthma. The …
epidemiological studies suggest that DIDP is associated with the occurrence of asthma. The …
Cellular response of THP-1 macrophages to polystyrene microplastics exposure
Microplastic in the environment have the capability to reach the human immune system via
the ingestion, inhalation and direct contact. Polystyrene (PS) is one of the most widely used …
the ingestion, inhalation and direct contact. Polystyrene (PS) is one of the most widely used …
Dibutyl phthalate aggravated asthma-like symptoms through oxidative stress and increasing calcitonin gene-related peptide release
S Zhou, M Han, Y Ren, X Yang, L Duan, Y Zeng… - … and Environmental Safety, 2020 - Elsevier
Dibutyl phthalate (DBP) is one of the most ubiquitous phthalate esters found in everyday
products, and is receiving increased attention as an immunologic adjuvant. However …
products, and is receiving increased attention as an immunologic adjuvant. However …
Mediation of endoplasmic reticulum stress and NF-κB signaling pathway in DINP-exacerbated allergic asthma: A toxicological study with Balb/c mice
F Lei, Y Wu, C Li, B Yan, S Chen, Q Peng… - Journal of Hazardous …, 2023 - Elsevier
Epidemiological evidence indicates a significant relationship between exposure to
diisononyl phthalate and allergic asthma. Despite this, the mechanism underlying this …
diisononyl phthalate and allergic asthma. Despite this, the mechanism underlying this …
Polystyrene microplastic particles induce autophagic cell death in BEAS‐2B human bronchial epithelial cells
MS Jeon, JW Kim, YB Han, MH Jeong… - Environmental …, 2023 - Wiley Online Library
The detection of high levels of microplastics in indoor and outdoor air has increased
concerns regarding its toxic effects on the respiratory system. They are not easily …
concerns regarding its toxic effects on the respiratory system. They are not easily …
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