Modulating TRADD to restore cellular homeostasis and inhibit apoptosis
Cell death in human diseases is often a consequence of disrupted cellular homeostasis. If
cell death is prevented without restoring cellular homeostasis, it may lead to a persistent …
cell death is prevented without restoring cellular homeostasis, it may lead to a persistent …
Caspase-2 cleavage of tau reversibly impairs memory
X Zhao, LA Kotilinek, B Smith, C Hlynialuk, K Zahs… - Nature medicine, 2016 - nature.com
In Alzheimer's disease (AD) and other tauopathies, the tau protein forms fibrils, which are
believed to be neurotoxic. However, fibrillar tau has been dissociated from neuron death …
believed to be neurotoxic. However, fibrillar tau has been dissociated from neuron death …
[HTML][HTML] The adaptor protein TRADD activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm
LM Bender, MJ Morgan, LR Thomas, ZG Liu… - Cell Death & …, 2005 - nature.com
TNFR1 associated death domain protein (TRADD) contains an N-terminal TRAF binding
domain and a C-terminal death domain along with nuclear import and export sequences that …
domain and a C-terminal death domain along with nuclear import and export sequences that …
Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice
Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease that
is characterized by motor neuron loss and that leads to paralysis and death 2–5 years after …
is characterized by motor neuron loss and that leads to paralysis and death 2–5 years after …
RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development
H Anderton, E Bandala-Sanchez, DS Simpson… - Cell Death & …, 2019 - nature.com
RIPK1 is an essential downstream component of many pattern recognition and death
receptors. RIPK1 can promote the activation of caspase-8 induced apoptosis and RIPK3 …
receptors. RIPK1 can promote the activation of caspase-8 induced apoptosis and RIPK3 …
[HTML][HTML] TRAF2 Sets a threshold for extrinsic apoptosis by tagging caspase-8 with a ubiquitin shutoff timer
F Gonzalvez, D Lawrence, B Yang, S Yee, R Pitti… - Molecular cell, 2012 - cell.com
Apoptotic caspase activation mechanisms are well defined, yet inactivation modes remain
unclear. The death receptors (DRs), DR4, DR5, and Fas, transduce cell-extrinsic apoptotic …
unclear. The death receptors (DRs), DR4, DR5, and Fas, transduce cell-extrinsic apoptotic …
A role for caspase-8 and TRAIL-R2/DR5 in ER-stress-induced apoptosis
C Muñoz-Pinedo, A López-Rivas - Cell Death & Differentiation, 2018 - nature.com
Glab et al. 1 examined in a recent paper apoptosis induced by some drivers of endoplasmic
reticulum (ER) stress. They conclude that in contrast to a previously published report, 2 …
reticulum (ER) stress. They conclude that in contrast to a previously published report, 2 …
Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1
Stimulation of tumor necrosis factor receptor 1 (TNFR1) can initiate several cellular
responses, including apoptosis, which relies on caspases, necrotic cell death, which …
responses, including apoptosis, which relies on caspases, necrotic cell death, which …
[HTML][HTML] Redundant and receptor-specific activities of TRADD, RIPK1 and FADD in death receptor signaling
S Füllsack, A Rosenthal, H Wajant, D Siegmund - Cell death & disease, 2019 - nature.com
We evaluated redundant and receptor-specific activities of TRADD, RIPK1, and FADD in
RIPK3-expressing HeLa cells lacking expression of these proteins or any combination of two …
RIPK3-expressing HeLa cells lacking expression of these proteins or any combination of two …
Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline
TJ Bussian, A Aziz, CF Meyer, BL Swenson… - Nature, 2018 - nature.com
Cellular senescence, which is characterized by an irreversible cell-cycle arrest
accompanied by a distinctive secretory phenotype, can be induced through various …
accompanied by a distinctive secretory phenotype, can be induced through various …