Cell death in human diseases is often a consequence of disrupted cellular homeostasis. If
cell death is prevented without restoring cellular homeostasis, it may lead to a persistent …

In Alzheimer's disease (AD) and other tauopathies, the tau protein forms fibrils, which are
believed to be neurotoxic. However, fibrillar tau has been dissociated from neuron death …

TNFR1 associated death domain protein (TRADD) contains an N-terminal TRAF binding
domain and a C-terminal death domain along with nuclear import and export sequences that …

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease that
is characterized by motor neuron loss and that leads to paralysis and death 2–5 years after …

RIPK1 is an essential downstream component of many pattern recognition and death
receptors. RIPK1 can promote the activation of caspase-8 induced apoptosis and RIPK3 …

Apoptotic caspase activation mechanisms are well defined, yet inactivation modes remain
unclear. The death receptors (DRs), DR4, DR5, and Fas, transduce cell-extrinsic apoptotic …

Glab et al. 1 examined in a recent paper apoptosis induced by some drivers of endoplasmic
reticulum (ER) stress. They conclude that in contrast to a previously published report, 2 …

Stimulation of tumor necrosis factor receptor 1 (TNFR1) can initiate several cellular
responses, including apoptosis, which relies on caspases, necrotic cell death, which …

We evaluated redundant and receptor-specific activities of TRADD, RIPK1, and FADD in
RIPK3-expressing HeLa cells lacking expression of these proteins or any combination of two …

Cellular senescence, which is characterized by an irreversible cell-cycle arrest
accompanied by a distinctive secretory phenotype, can be induced through various …