[HTML][HTML] The use of untargeted and widely targeted metabolomics to distinguish between asphyxia and sudden cardiac death as the cause of death in rats: A …

K Zhang, Y Tuo, R Liu, H Yan, P Xiang, Z Wang… - Arabian Journal of …, 2022 - Elsevier
It is important to determine the cause of death in the case of asphyxia. However, it is difficult
to conclude death by asphyxia, especially when the deceased has underlying heart disease …

Exploring metabolic alterations associated with death from asphyxia and the differentiation of asphyxia from sudden cardiac death by GC-HRMS-based untargeted …

K Zhang, H Yan, R Liu, P Xiang, K Deng… - … of Chromatography B, 2021 - Elsevier
The determination of cause of death is one of the most important tasks in forensic practice.
However, asphyxia is a difficult cause of death to determine, especially when the deceased …

The use of gas chromatography coupled with high-resolution mass spectrometry-based untargeted metabolomics to discover metabolic changes and help in the …

K Zhang, H Yan, R Liu, P Xiang, J Zhang, K Deng… - ACS …, 2021 - ACS Publications
The determination of cause of death (COD) is one of the most important tasks in forensic
practice and is mainly based on macroscopical and microscopical morphological signatures …

Forensic identification of sudden cardiac death: a new approach combining metabolomics and machine learning

J Cao, X Wei, MF Liu, GS An, J Li, QX Du… - Analytical and …, 2023 - Springer
The determination of sudden cardiac death (SCD) is one of the difficult tasks in the forensic
practice, especially in the absence of specific morphological changes in the autopsies and …

Post-mortem metabolomics: a novel approach in clinical biomarker discovery and a potential tool in death investigations

A Elmsjo, S Vikingsson, C Soderberg… - Chemical Research …, 2021 - ACS Publications
Metabolomics can be defined as the scientific field aiming at characterizing all low-weight
molecules (so-called metabolites) in a biological system. At the time of death, the level and …

Metabolic signatures in apoptotic human cancer cell lines

A Halama, G Möller, J Adamski - Omics: a journal of integrative …, 2011 - liebertpub.com
Cancer cells have several specific metabolic features, which have been explored for
targeted therapies. Agents that promote apoptosis in tumors are currently considered as a …

Metabolomics of post-mortem blood: identifying potential markers of post-mortem interval

AE Donaldson, IL Lamont - Metabolomics, 2015 - Springer
Death results in changes in some metabolites in body tissues due to lack of circulating
oxygen, altered enzymatic reactions, cellular degradation, and cessation of anabolic …

Combined metabolomics and machine learning algorithms to explore metabolic biomarkers for diagnosis of acute myocardial ischemia

J Cao, J Li, Z Gu, J Niu, G An, Q Jin, Y Wang… - International Journal of …, 2023 - Springer
Acute myocardial ischemia (AMI) remains the leading cause of death worldwide, and the
post-mortem diagnosis of AMI represents a current challenge for both clinical and forensic …

Serum Metabolomics Reveals Distinct Profiles during Ischemia and Reperfusion in a Porcine Model of Myocardial Ischemia–Reperfusion

E Goetzman, Z Gong, D Rajasundaram… - International Journal of …, 2022 - mdpi.com
Acute myocardial infarction (MI) is one of the leading causes of death worldwide. Early
identification of ischemia and establishing reperfusion remain cornerstones in the treatment …

Metabolomics profiling reveals different patterns in an animal model of asphyxial and dysrhythmic cardiac arrest

D Varvarousis, T Xanthos, G Ferino, A Noto… - Scientific Reports, 2017 - nature.com
Cardiac arrest (CA) is not a uniform condition and its pathophysiology strongly depends on
its cause. In this work we have used a metabolomics approach to study the dynamic …