Pulmonary arteries of patients with severe pulmonary hypertension (SPH) presenting in an
idiopathic form (primary PH‐PPH) or associated with congenital heart malformations or …

The pulmonary vasculature exhibits various morphological changes in patients with
pulmonary hypertension (PH). Among them, the plexiform lesion is one of the most …

The plexiform lesions of severe pulmonary hypertension (PH) are complex vascular
structures composed primarily of endothelial cells. In this study, we use …

Background—The plexiform lesion is the hallmark of severe pulmonary arterial
hypertension. However, its genesis and hemodynamic effects are largely unknown because …

Pulmonary arterial hypertension (PAH) is a debilitating disease with a high mortality rate. A
hallmark of PAH is plexiform lesions (PLs), complex vascular formations originating from …

Congenital heart disease (CHD) leading to increased pulmonary blood pressure and flow is
an important cause of pulmonary plexogenic arteriopathy (PPA). This type of arteriopathy …

Severe pulmonary arterial hypertension (PAH) occurs in idiopathic form and in association
with diverse diseases. The pathological hallmarks are distal smooth muscle hypertrophy …

We investigated the distribution of pulmonary arteriopathy in chronic pulmonary
hypertension (PH) in a quantitative histopathologic study, using computer-assisted image …

The plexiform lesion in primary pulmonary hypertension is a glomeruloid structure forming
channels in branches of the pulmonary artery. These lesions have been considered an …

Severe pulmonary arterial hypertension, whether idiopathic or secondary, is characterized
by structural alterations of microscopically small pulmonary arterioles. The vascular lesions …