Computational models link cellular mechanisms of neuromodulation to large-scale neural dynamics
Decades of neurobiological research have disclosed the diverse manners in which the
response properties of neurons are dynamically modulated to support adaptive cognitive …
response properties of neurons are dynamically modulated to support adaptive cognitive …
Mapping how local perturbations influence systems-level brain dynamics
The human brain exhibits a distinct spatiotemporal organization that supports brain function
and can be manipulated via local brain stimulation. Such perturbations to local cortical …
and can be manipulated via local brain stimulation. Such perturbations to local cortical …
Bridging single neuron dynamics to global brain states
Biological neural networks produce information backgrounds of multi-scale spontaneous
activity that become more complex in brain states displaying higher capacities for cognition …
activity that become more complex in brain states displaying higher capacities for cognition …
Dynamic models of large-scale brain activity
M Breakspear - Nature neuroscience, 2017 - nature.com
Movement, cognition and perception arise from the collective activity of neurons within
cortical circuits and across large-scale systems of the brain. While the causes of single …
cortical circuits and across large-scale systems of the brain. While the causes of single …
Multiple models to capture the variability in biological neurons and networks
How tightly tuned are the synaptic and intrinsic properties that give rise to neuron and circuit
function? Experimental work shows that these properties vary considerably across identified …
function? Experimental work shows that these properties vary considerably across identified …
Neuromodulation of circuits with variable parameters: single neurons and small circuits reveal principles of state-dependent and robust neuromodulation
Neuromodulation underlies many behavioral states and has been extensively studied in
small circuits. This has allowed the systematic exploration of how neuromodulatory …
small circuits. This has allowed the systematic exploration of how neuromodulatory …
On simplicity and complexity in the brave new world of large-scale neuroscience
P Gao, S Ganguli - Current opinion in neurobiology, 2015 - Elsevier
Technological advances have dramatically expanded our ability to probe multi-neuronal
dynamics and connectivity in the brain. However, our ability to extract a simple conceptual …
dynamics and connectivity in the brain. However, our ability to extract a simple conceptual …
[HTML][HTML] The quest for multiscale brain modeling
E D'Angelo, V Jirsa - Trends in neurosciences, 2022 - cell.com
Addressing the multiscale organization of the brain, which is fundamental to the dynamic
repertoire of the organ, remains challenging. In principle, it should be possible to model …
repertoire of the organ, remains challenging. In principle, it should be possible to model …
Large-scale neural recordings call for new insights to link brain and behavior
Neuroscientists today can measure activity from more neurons than ever before, and are
facing the challenge of connecting these brain-wide neural recordings to computation and …
facing the challenge of connecting these brain-wide neural recordings to computation and …
Data-driven multiscale computational models of cortical and subcortical regions
S Ramaswamy - Current opinion in neurobiology, 2024 - Elsevier
Data-driven computational models of neurons, synapses, microcircuits, and mesocircuits
have become essential tools in modern brain research. The goal of these multiscale models …
have become essential tools in modern brain research. The goal of these multiscale models …