Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a
remarkable range of functions in normal and injured liver. Derived embryologically from …

Hepatic stellate cells (HSCs), a mesenchymal cell type in hepatic parenchyma, have unique
features with respect to their cellular origin, morphology, and function. Normal, quiescent …

Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular
matrix resulting from chronic liver injury of any aetiology, including viral infection, alcoholic …

The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

The last decade has seen a rapid expansion in our understanding of the mechanisms
leading to hepatic stellate cell activation. The classic activation pathway of initiation …

leading to an understanding that is increasingly nuanced. A clear example is the paper of
Magness and coworkers1 in this issue of HEPATOLOGY, which explores the topic of stellate …

Progressive liver fibrosis, induced by chronic viral and metabolic disorders, leads to more
than one million deaths annually via development of cirrhosis, although no antifibrotic …

Hepatic stellate cells are liver-specific mesenchymal cells that play vital roles in liver
physiology and fibrogenesis. They are located in the space of Disse and maintain close …

Substantial improvements in the treatment of chronic liver disease have accelerated interest
in uncovering the mechanisms underlying hepatic fibrosis and its resolution. Activation of …

Hepatic stellate cells (HSC) are characterized by their perisinusoidal localization and their
long processes extending along and around sinusoids and between hepatocytes. Electron …