Direct oral anticoagulants: what will be their role in children?

C Male, K Thom, SH O'Brien - Thrombosis research, 2019 - Elsevier
Thrombotic events in children differ from those in adults in epidemiology, pathophysiology,
and anatomical location. However, anticoagulation in children is mostly based on evidence …

[HTML][HTML] Anticoagulant prophylaxis and therapy in children: current challenges and emerging issues

F Newall, B Branchford, C Male - Journal of Thrombosis and Haemostasis, 2018 - Elsevier
This review is aimed at describing the unique challenges of anticoagulant prophylaxis and
treatment in children, and highlighting areas for research for improving clinical outcomes of …

[HTML][HTML] What did we learn (and did not learn) from the pediatric direct oral anticoagulant trials, and how might we better design pediatric anticoagulant trials in the …

M Betensky, P Monagle, C Male… - Research and Practice in …, 2023 - Elsevier
A State of the Art lecture titled “What the direct oral anticoagulants (DOACs) trials did and
didn't tell us” was presented at the International Society on Thrombosis and Haemostasis …

[HTML][HTML] Use of direct oral anticoagulants in children and adolescents

M Albisetti - Hämostaseologie, 2020 - thieme-connect.com
While the need for anticoagulation in children has increased over the last decades, dose
regimens of currently used anticoagulants, including low-molecular-weight heparin (LMWH) …

Direct oral anticoagulants: novel approach for the treatment of thrombosis in pediatric patients?

J Mikler, M Samoš, T Bolek, I Škorňová… - Pediatric …, 2019 - Springer
Venous thromboembolism (VTE) is a rare, but life-threatening disease in those who have not
reached their adulthood. This condition is usually treated with heparin or low molecular …

[HTML][HTML] Current clinical trials on the use of direct oral anticoagulants in the pediatric population

E von Vajna, R Alam, TY So - Cardiology and Therapy, 2016 - Springer
Common treatment options for deep vein thrombosis and venous thromboembolism in the
pediatric population include unfractionated heparin, low molecular weight heparin, and …

Direct oral anticoagulants for use in paediatrics

J Jaffray, G Young - The Lancet Child & Adolescent Health, 2022 - thelancet.com
With the increasing incidence of thromboembolism in children and improvement in
management for patients with medically complex diseases, expanded availability of safe …

[HTML][HTML] Anticoagulation in pediatric patients

C Male - Hämostaseologie, 2022 - thieme-connect.com
Special aspects of anticoagulation in children include the different epidemiology of
thrombosis, developmental changes in the coagulation system, age-dependent …

[HTML][HTML] Practical considerations for use of direct oral anticoagulants in children

H Whitworth, L Raffini - Frontiers in Pediatrics, 2022 - frontiersin.org
Direct oral anticoagulants (DOACs) provide an attractive alternative for the management and
prevention of thrombosis in pediatric patients. With multiple ongoing and published pediatric …

Efficacy and safety of direct oral anticoagulants in the pediatric population: a systematic review and a meta-analysis

R Giossi, D Menichelli, F D'Amico, L Idotta… - Journal of Thrombosis …, 2023 - Elsevier
ABSTRACT Background Direct oral anticoagulants (DOACs) represent a cornerstone of
venous thromboembolism (VTE) treatment in adults. Recently, randomized controlled trials …