Cocaine blocks dopamine uptake via dopamine transporter (DAT) on plasma membrane of
neuron cells and, as a result, produces the high and induces DAT trafficking to plasma …

As well known, cocaine induces stimulant effects and dopamine transporter (DAT) trafficking
to the plasma membrane of dopaminergic neurons. In the present study, we examined …

Dysregulation of dopamine transporters (DAT) within the dopaminergic system is an
important biomarker of cocaine exposure. Depending on cocaine amount in‐taken, one …

In HEK 293 cells expressing the human dopamine transporter (DAT), a 10-min incubation
with 10 μM cocaine followed by extensive washing resulted in a 30% increase in [3H] …

The profound alterations produced by cocaine on dopamine (DA) neurotransmission raise
the possibility that dopamine transporter (DAT)-expressing neurons may modify DA transport …

The plasma membrane dopamine transporter (DAT) is responsible for clearing dopamine
from the synapse. Cocaine blockade of DAT leads to increased extracellular dopamine, an …

Cocaine produces its reinforcing effects primarily by inhibiting the dopamine transporter
(DAT) at the level of presynaptic terminals and increasing extracellular levels of dopamine …

The increase in extracellular dopamine (DA) following cocaine administration plays a major
role in cocaine abuse. In vitro, cocaine binds to DA transporters (DAT) and blocks DA …

The dopamine transporter is responsible for recycling dopamine after release. Inhibitors of
the dopamine transporter, such as cocaine, will stop the reuptake of dopamine and allow it …

Drugs of abuse, including cocaine, amphetamine (AMPH), and heroin, elevate extracellular
dopamine (DA) levels in the brain, thereby altering the activity/plasticity of reward circuits …