Antigen-presenting OKM5+ melanophages appear in human epidermis after ultraviolet radiation

KD Cooper, GR Neises, SI Katz - Journal of investigative dermatology, 1986 - Elsevier
Ultraviolet radiation of murine skin in vivo or epidermal cells (EC) in vitro dramatically
inhibits the antigen-presenting capacity of EC in vitro and results in the inhibition of immune …

Melanophages in inflammatory skin disease demonstrate the surface phenotype of OKM5+ antigen-presenting cells and activated macrophages

JS Weiss, WD James, KD Cooper - Journal of the American Academy of …, 1988 - Elsevier
Previous studies in our laboratory revealed that ultraviolet light induces the appearance of
epidermal melanophages that have potent antigen-presenting ability, that can activate …

Human epidermal cells from ultraviolet light-exposed skin preferentially activate autoreactive CD4+ 2H4+ suppressor-inducer lymphocytes and CD8+ suppressor …

O Baadsgaard, DA Fox, KD Cooper - Journal of immunology …, 1988 - journals.aai.org
In vivo exposure of human epidermis to UV abrogates the function of T6+ DR+ Langerhans
cells and induces the appearance of Ag-presenting T6-DR+ OKM5+ cells in the epidermis …

Dose response and time course for induction of T6− DR+ human epidermal antigen-presenting cells by in vivo ultraviolet A, B, and C irradiation

O Baadsgaard, KD Cooper, S Lisby, HC Wulf… - Journal of the American …, 1987 - Elsevier
In vivo ultraviolet (UV) exposure of human skin abrogates the antigen-presenting function of
T6+ DR+ Langerhans cells and induces the appearance of antigen-presenting T6− DR+ …

UVB and UVC, but not UVA, potently induce the appearance of T6-DR+ antigen-presenting cells in human epidermis

O Baadsgaard, HC Wulf, GL Wantzin… - Journal of investigative …, 1987 - Elsevier
Non-Langerhans cell, antigen-presenting T6-DR+ epidermal cells (EC) appear 3 days
following broad band ultraviolet radiation exposure of human skin and are responsible for …

Expression of OKM5 antigen on human keratinocytes in vitro upon stimulation with gamma-interferon.

J Hunyadi, M Simon Jr - Acta dermato-venereologica, 1986 - europepmc.org
Using murine monoclonal antibodies against human OKM5, OKM1 and HLA-DR antigens
antigenic characteristics of freshly separated human epidermal cells (EC) and those of EC …

Neutrophils, differentiated macrophages, and monocyte/macrophage antigen presenting cells infiltrate murine epidermis after UV injury

KD Cooper, N Duraiswamy, C Hammerberg… - Journal of investigative …, 1993 - Elsevier
We asked whether, as in humans, a population of antigen-presenting macrophages
infiltrates the epidermis of ultraviolet (UV)-exposed BALB/c mice. Using three-color flow …

Expression of OKM5 antigen on human keratinocytes in positive intracutaneous tests for delayed-type hypersensitivity

M Simon, Jr, J Hunyadi - Dermatology, 1987 - karger.com
Antigenic characteristics of human keratinocytes (HK) were studied in positive
intracutaneous tests for delayed-type hypersensitivity in vivo using murine monoclonal …

Epidermal Langerhans cells are not required for UV-induced immunosuppression

L Wang, SC Jameson, KA Hogquist - The Journal of Immunology, 2009 - journals.aai.org
UV light can be highly beneficial in the treatment of skin disorders such as psoriasis. It is
thought to cause immunosuppression by depleting or altering the function of epidermal …

Effects of ultraviolet radiation on human epidermal cell alloantigen presentation: initial depression of Langerhans cell-dependent function is followed by the …

KD Cooper, P Fox, G Neises, SI Katz - Journal of immunology …, 1985 - journals.aai.org
The effects of ultraviolet radiation (UV) on the immune parameters of human epidermis were
studied. We determined the effects of both in vitro and in vivo UV on human epidermal cell …