Genetic determinants of methotrexate toxicity in rheumatoid arthritis patients: a study of polymorphisms affecting methotrexate transport and folate metabolism
P Bohanec Grabar, D Logar, B Lestan… - European journal of …, 2008 - Springer
Objective Methotrexate (MTX) is a disease-modifying antirheumatic drug used in the
treatment of rheumatoid arthritis (RA). Genetic polymorphisms of reduced folate carrier …
treatment of rheumatoid arthritis (RA). Genetic polymorphisms of reduced folate carrier …
Genetic determinants of methotrexate toxicity in tunisian patients with rheumatoid arthritis: a study of polymorphisms involved in the MTX metabolic pathway
S Chaabane, S Marzouk, R Akrout… - European journal of …, 2016 - Springer
Abstract Background and Objective Methotrexate (MTX) is a disease-modifying anti-
rheumatic drug used in the treatment of rheumatoid arthritis (RA). It is the first line drug in the …
rheumatic drug used in the treatment of rheumatoid arthritis (RA). It is the first line drug in the …
Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis.
P Ranganathan, R Culverhouse, S Marsh… - The Journal of …, 2008 - jrheum.org
OBJECTIVE: Research has examined the association of folate-dependent gene
polymorphisms with methotrexate (MTX) toxicity in racially homogenous patients with …
polymorphisms with methotrexate (MTX) toxicity in racially homogenous patients with …
Metaanalysis of methylenetetrahydrofolate reductase (MTHFR) polymorphisms affecting methotrexate toxicity
MC Fisher, BN Cronstein - The Journal of rheumatology, 2009 - jrheum.org
Objective. Methotrexate (MTX) is an effective therapy for rheumatoid arthritis (RA) but it is
also associated with toxicity. Pharmacogenetics is the systematic evaluation of the role of …
also associated with toxicity. Pharmacogenetics is the systematic evaluation of the role of …
Association of the MTHFR C677T and A1298C polymorphisms with methotrexate toxicity in rheumatoid arthritis: a meta-analysis
GG Song, SC Bae, YH Lee - Clinical rheumatology, 2014 - Springer
The aim of this study was to explore whether the C677T and A1298C polymorphisms of
methylenetetrahydrofolate reductase (MTHFR) play a role in methotrexate (MTX) toxicity in …
methylenetetrahydrofolate reductase (MTHFR) play a role in methotrexate (MTX) toxicity in …
[PDF][PDF] Association of dihydrofolate reductase (DHFR)-317AA genotype with poor response to methotrexate in patients with rheumatoid arthritis
V Milic, B Jekic, L Lukovic, V Bunjevacki… - Clinical and …, 2012 - clinexprheumatol.org
Objectives Identifying genetic predictors of methotrexate (MTX) treatment response in
patients with rheumatoid arthritis (RA) may have great importance for optimising drug doses …
patients with rheumatoid arthritis (RA) may have great importance for optimising drug doses …
Association Between MTHFR C677T Polymorphism and Methotrexate Treatment Outcome in Rheumatoid Arthritis Patients: A Systematic Review and Meta-Analysis
W Shao, Y Yuan, Y Li - Genetic Testing and Molecular Biomarkers, 2017 - liebertpub.com
Purpose: Methotrexate (MTX) is one of the most widely used disease-modifying
antirheumatic drugs for the treatment of rheumatoid arthritis (RA). However, its efficacy in RA …
antirheumatic drugs for the treatment of rheumatoid arthritis (RA). However, its efficacy in RA …
Are Thymidylate synthase and Methylene tetrahydrofolate reductase genes linked with methotrexate response (efficacy, toxicity) in Indian (Asian) rheumatoid arthritis …
Methotrexate (MTX) is among the best-tolerated disease-modifying antirheumatic drugs for
the treatment of rheumatoid arthritis (RA); major drawbacks of MTX therapy are the large …
the treatment of rheumatoid arthritis (RA); major drawbacks of MTX therapy are the large …
677C>T and 1298A>C MTHFR polymorphisms affect methotrexate treatment outcome in rheumatoid arthritis
M Kurzawski, A Pawlik, K Safranow, M Herczynska… - 2007 - Future Medicine
Introduction: Methotrexate (MTX), widely used in the treatment of rheumatoid arthritis (RA),
inhibits dihydrofolate reductase and folate-dependent enzymes. Methylenetetrahydrofolate …
inhibits dihydrofolate reductase and folate-dependent enzymes. Methylenetetrahydrofolate …
Methylene tetrahydrofolate reductase gene polymorphisms and their association with methotrexate toxicity: a meta-analysis
KP Spyridopoulou, NL Dimou… - Pharmacogenetics …, 2012 - journals.lww.com
Objective A systematic review and a meta-analysis were conducted, to investigate the
possible association of methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms …
possible association of methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms …
相关搜索
- methotrexate toxicity rheumatoid arthritis
- methotrexate toxicity genetic determinants
- methotrexate toxicity meta analysis
- methotrexate transport arthritis patients
- methotrexate transport folate metabolism
- folate metabolism arthritis patients
- genetic determinants folate metabolism
- methotrexate toxicity mthfr polymorphisms
- genetic determinants arthritis patients
- mthfr polymorphisms rheumatoid arthritis
- methotrexate toxicity tunisian patients
- american patients rheumatoid arthritis
- meta analysis arthritis patients
- methotrexate toxicity methylenetetrahydrofolate reductase
- methotrexate in patients poor response
- thymidylate synthase arthritis patients