Silencing RNA (siRNA) technologies attract significant interest as a therapeutic tool for a
large number of diseases. However, the medical translation of this technology is hampered …

In this study, a series of bioreducible poly (amidoamine) s grafting different percentages of
cholesterol (rPAA-Ch14: 14%, rPAA-Ch29: 29%, rPAA-Ch57: 57% and rPAA-Ch87: 87%) …

The affinity of a synthetic polymer nanoparticle (NP) to a target biomacromolecule is
determined by the association and dissociation rate constants (k on, k off) of the interaction …

To exploit the full therapeutic potential of short interfering RNA (siRNA), efficient delivery
vehicles are needed as siRNA fails to enter cells spontaneously. Such carriers should also …

Purpose Polyelectrolyte complex nanoparticles are a promising vehicle for siRNA delivery
but suffer from low stability under physiological conditions. An effective stabilization method …

Small interfering RNAs (siRNA) are attractive and powerful tools to inhibit the expression of
a targeted gene. However, their extreme hydrophilicities combined with a negative charge …

Small interference RNA (siRNA) is a tool for gene modulation, which can silence any gene
involved in genetic disorders. The potential of this therapeutic tool is hampered by RNA …

Silencing RNA (siRNA) technologies emerge as a promising therapeutic tool for the
treatment of multiple diseases. An ideal nanocarrier (NC) for siRNAs should be stable at …

Amphiphilic compounds consisting of polycations and lipid segments are well established
as building blocks for the construction of siRNA carriers. They are capable of forming …

RNA interference (RNAi) is a promising approach to the treatment of genetic diseases by the
specific knockdown of target genes. Functional polymers are potential vehicles for the …