Pharmacology and structure of P2Y receptors
I von Kügelgen, K Hoffmann - Neuropharmacology, 2016 - Elsevier
Abstract P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular
nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y 1, P2Y 2, P2Y 4, P2Y …
nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y 1, P2Y 2, P2Y 4, P2Y …
Pharmacology of P2Y receptors
I von Kügelgen - Brain research bulletin, 2019 - Elsevier
Abstract P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular
nucleotides. There are eight mammalian P2Y receptor subtypes divided into two subgroups …
nucleotides. There are eight mammalian P2Y receptor subtypes divided into two subgroups …
Molecular pharmacology of P2Y receptor subtypes
I von Kuegelgen - Biochemical Pharmacology, 2021 - Elsevier
Abstract Professor Geoffrey Burnstock proposed the concept of purinergic signaling via P1
and P2 receptors. P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular …
and P2 receptors. P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular …
Structure of the human P2Y12 receptor in complex with an antithrombotic drug
Abstract P2Y receptors (P2YRs), a family of purinergic G-protein-coupled receptors
(GPCRs), are activated by extracellular nucleotides. There are a total of eight distinct …
(GPCRs), are activated by extracellular nucleotides. There are a total of eight distinct …
Pharmacological profiles of cloned mammalian P2Y-receptor subtypes
I von Kügelgen - Pharmacology & therapeutics, 2006 - Elsevier
Membrane-bound P2-receptors mediate the actions of extracellular nucleotides in cell-to-
cell signalling. P2X-receptors are ligand-gated ion channels, whereas P2Y-receptors belong …
cell signalling. P2X-receptors are ligand-gated ion channels, whereas P2Y-receptors belong …
P2Y12 receptors in platelets and other hematopoietic and non-hematopoietic cells
C Gachet - Purinergic signalling, 2012 - Springer
The P2Y 12 receptor is a Gi-coupled ADP receptor first described in blood platelets where it
plays a central role in the complex processes of activation and aggregation. Platelet …
plays a central role in the complex processes of activation and aggregation. Platelet …
International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy
MP Abbracchio, G Burnstock, JM Boeynaems… - Pharmacological …, 2006 - ASPET
There have been many advances in our knowledge about different aspects of P2Y receptor
signaling since the last review published by our International Union of Pharmacology …
signaling since the last review published by our International Union of Pharmacology …
Identification of the P2Y12 receptor: a novel member of the P2Y family of receptors activated by extracellular nucleotides
RA Nicholas - Molecular Pharmacology, 2001 - ASPET
The action of extracellular nucleotides, specifically the ability of adenine nucleotides to
induce coronary vasodilation and bradycardia, was first described more than 70 years ago …
induce coronary vasodilation and bradycardia, was first described more than 70 years ago …
P2Y receptors: focus on structural, pharmacological and functional aspects in the brain
W Fischer, U Krugel - Current medicinal chemistry, 2007 - ingentaconnect.com
Purine and pyrimidine nucleotides have been identified as potent extracellular signalling
molecules, acting at two classes of cell surface receptors, ionotropic P2X and metabotropic …
molecules, acting at two classes of cell surface receptors, ionotropic P2X and metabotropic …
Molecular pharmacology, physiology, and structure of the P2Y receptors
I von Kügelgen, TK Harden - Advances in pharmacology, 2011 - Elsevier
The P2Y receptors are a widely expressed group of eight nucleotide-activated G protein-
coupled receptors (GPCRs). The P2Y 1 (ADP), P2Y 2 (ATP/UTP), P2Y 4 (UTP), P2Y 6 …
coupled receptors (GPCRs). The P2Y 1 (ADP), P2Y 2 (ATP/UTP), P2Y 4 (UTP), P2Y 6 …