Abstract gamma-Aminobutyric acid (GABA)-mediated inhibitory neurotransmission and the
gene products involved were discovered during the mid-twentieth century. Historically …

GABA A receptors are Cl− channels that can be opened by GABA and are the major
inhibitory neurotransmitter receptors in the CNS. A variety of pharmacologically important …

Publisher Summary This chapter describes the structure, pharmacology, and function of γ‐
aminobutyric acid type A (GABA A) receptor subtypes. GABA A receptors are the most …

GABA (1, 4-aminobutanoic acid, γ-aminobutyric acid) is the major inhibitory neurotransmitter
in the brain and is essential for the overall balance between neuronal excitation and …

Abstract GABA A receptors (GABA A Rs) mediate rapid inhibitory transmission in the brain.
GABA A Rs are ligand-gated chloride ion channel proteins and exist in about a dozen or …

Abstract γ-Aminobutyric acid (GABA), an amino acid neurotransmitter, is widely distributed
throughout the neuraxis. Two pharmacologically and molecularly distinct GABA receptors …

The amino acid γ-aminobutyric-acid (GABA) prevails in the CNS as an inhibitory neurotrans-
mitter that mediates most of its effects through fast GABA-gated Cl−-channels (GABA AR) …

The γ-aminobutyric acid type A (GABAA) receptors are the major inhibitory neuronal
receptors in the mammalian brain. Their activation by GABA opens the intrinsic ion channel …

GABAA receptors are the major inhibitory transmitter receptors in the brain. They are ligand-
gated chloride channels and the site of action of benzodiazepines, barbiturates, neuroactive …

The enhancement of GABA-mediated synaptic transmission underlies the pharmacotherapy
of various neurological and psychiatric disorders. GABA A receptors are pluripotent drug …