Aberrant astrocyte protein secretion contributes to altered neuronal development in multiple models of neurodevelopmental disorders

ALM Caldwell, L Sancho, J Deng, A Bosworth… - Nature …, 2022 - nature.com
Astrocytes negatively impact neuronal development in many models of neurodevelopmental
disorders (NDs); however, how they do this, and if mechanisms are shared across disorders …

Astrocyte development: a guide for the perplexed

AV Molofsky, B Deneen - Glia, 2015 - Wiley Online Library
Astrocytes are the predominant cell type in the brain and perform key functions vital to CNS
physiology, including blood brain barrier formation and maintenance, synaptogenesis …

A stocked toolbox for understanding the role of astrocytes in disease

A Almad, NJ Maragakis - Nature Reviews Neurology, 2018 - nature.com
Our understanding of astrocytes and their role in neurological diseases has increased
considerably over the past two decades as the diverse roles of these cells have become …

[HTML][HTML] Activity-dependent modulation of synapse-regulating genes in astrocytes

I Farhy-Tselnicker, MM Boisvert, H Liu, C Dowling… - Elife, 2021 - elifesciences.org
Astrocytes regulate the formation and function of neuronal synapses via multiple signals;
however, what controls regional and temporal expression of these signals during …

Foundations and implications of astrocyte heterogeneity during brain development and disease

AL Schober, LE Wicki-Stordeur, KK Murai… - Trends in …, 2022 - cell.com
Astrocytes play crucial roles in regulating brain circuit formation and physiology. Recent
technological advances have revealed unprecedented levels of astrocyte diversity …

[HTML][HTML] Developmental maturation of astrocytes and pathogenesis of neurodevelopmental disorders

Y Yang, H Higashimori, L Morel - Journal of neurodevelopmental disorders, 2013 - Springer
Recent studies have implicated potentially significant roles for astrocytes in the
pathogenesis of neurodevelopmental disorders. Astrocytes undergo a dramatic maturation …

[HTML][HTML] Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain

S Sirko, C Schichor, P Della Vecchia, F Metzger… - Nature Medicine, 2023 - nature.com
The glial environment influences neurological disease progression, yet much of our
knowledge still relies on preclinical animal studies, especially regarding astrocyte …

[HTML][HTML] BMP signaling in astrocytes downregulates EGFR to modulate survival and maturation

AR Scholze, LC Foo, S Mulinyawe, BA Barres - PloS one, 2014 - journals.plos.org
Astrocytes constitute a major cell population in the brain with a myriad of essential functions,
yet we know remarkably little about the signaling pathways and mechanisms that direct …

[HTML][HTML] Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism

P Hasel, O Dando, Z Jiwaji, P Baxter, AC Todd… - Nature …, 2017 - nature.com
The influence that neurons exert on astrocytic function is poorly understood. To investigate
this, we first developed a system combining cortical neurons and astrocytes from closely …

Astrocyte form and function in the developing central nervous system

LS Chaboub, B Deneen - Seminars in pediatric neurology, 2013 - Elsevier
Astrocytes have long been forgotten entities in our quest to understand brain function. Over
the last few decades, there has been an exponential increase in our knowledge of central …