Aberrant astrocyte protein secretion contributes to altered neuronal development in multiple models of neurodevelopmental disorders
ALM Caldwell, L Sancho, J Deng, A Bosworth… - Nature …, 2022 - nature.com
Astrocytes negatively impact neuronal development in many models of neurodevelopmental
disorders (NDs); however, how they do this, and if mechanisms are shared across disorders …
disorders (NDs); however, how they do this, and if mechanisms are shared across disorders …
Astrocyte development: a guide for the perplexed
AV Molofsky, B Deneen - Glia, 2015 - Wiley Online Library
Astrocytes are the predominant cell type in the brain and perform key functions vital to CNS
physiology, including blood brain barrier formation and maintenance, synaptogenesis …
physiology, including blood brain barrier formation and maintenance, synaptogenesis …
A stocked toolbox for understanding the role of astrocytes in disease
A Almad, NJ Maragakis - Nature Reviews Neurology, 2018 - nature.com
Our understanding of astrocytes and their role in neurological diseases has increased
considerably over the past two decades as the diverse roles of these cells have become …
considerably over the past two decades as the diverse roles of these cells have become …
[HTML][HTML] Activity-dependent modulation of synapse-regulating genes in astrocytes
Astrocytes regulate the formation and function of neuronal synapses via multiple signals;
however, what controls regional and temporal expression of these signals during …
however, what controls regional and temporal expression of these signals during …
Foundations and implications of astrocyte heterogeneity during brain development and disease
AL Schober, LE Wicki-Stordeur, KK Murai… - Trends in …, 2022 - cell.com
Astrocytes play crucial roles in regulating brain circuit formation and physiology. Recent
technological advances have revealed unprecedented levels of astrocyte diversity …
technological advances have revealed unprecedented levels of astrocyte diversity …
[HTML][HTML] Developmental maturation of astrocytes and pathogenesis of neurodevelopmental disorders
Y Yang, H Higashimori, L Morel - Journal of neurodevelopmental disorders, 2013 - Springer
Recent studies have implicated potentially significant roles for astrocytes in the
pathogenesis of neurodevelopmental disorders. Astrocytes undergo a dramatic maturation …
pathogenesis of neurodevelopmental disorders. Astrocytes undergo a dramatic maturation …
[HTML][HTML] Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain
S Sirko, C Schichor, P Della Vecchia, F Metzger… - Nature Medicine, 2023 - nature.com
The glial environment influences neurological disease progression, yet much of our
knowledge still relies on preclinical animal studies, especially regarding astrocyte …
knowledge still relies on preclinical animal studies, especially regarding astrocyte …
[HTML][HTML] BMP signaling in astrocytes downregulates EGFR to modulate survival and maturation
AR Scholze, LC Foo, S Mulinyawe, BA Barres - PloS one, 2014 - journals.plos.org
Astrocytes constitute a major cell population in the brain with a myriad of essential functions,
yet we know remarkably little about the signaling pathways and mechanisms that direct …
yet we know remarkably little about the signaling pathways and mechanisms that direct …
[HTML][HTML] Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism
The influence that neurons exert on astrocytic function is poorly understood. To investigate
this, we first developed a system combining cortical neurons and astrocytes from closely …
this, we first developed a system combining cortical neurons and astrocytes from closely …
Astrocyte form and function in the developing central nervous system
LS Chaboub, B Deneen - Seminars in pediatric neurology, 2013 - Elsevier
Astrocytes have long been forgotten entities in our quest to understand brain function. Over
the last few decades, there has been an exponential increase in our knowledge of central …
the last few decades, there has been an exponential increase in our knowledge of central …