When the double-stranded helix of nucleic acids is influenced by conditions such as
increase the temperature of the solution, change pH and chemical agent (formamide …

Monovalent and divalent cations play a crucial role in living cells and for molecular
techniques such as PCR. Here we evaluate DNA melting temperatures in magnesium (Mg …

TNA/DNA hybrids share several similarities to RNA/DNA, such as the tendency to form A-
type helices and a strong dependency of their thermodynamic properties on …

DNA is a negatively charged biopolymer composed of monomeric nucleotides each carrying
on average a net (− 1) charge concentrated in the region of the phosphate backbone. In …

Despite the importance of DNA/RNA hybrids, a mesoscopic approach is still missing. We
developed a mesoscopic model for DNA/RNA hybrids and obtained the complete …

The stability and dynamics of a double-stranded DNA (dsDNA) is affected by the preferential
occupancy of small monovalent molecular ions. Small metal and molecular ions such as …

A molecular thermodynamic model is developed to predict DNA melting in ionic and
crowded solutions. Each pair of nucleotides in the double-stranded DNA and each …

DNA is a highly charged polyanion, whose structure, flexibility and biological functionality
are strongly influenced by the interactions with solvent and counterions. In recent years it …

Ion mediated interactions between nucleic acids helices are essential for their efficient
packaging within tight spaces such as viral capsids, sperm heads, and cell nuclei. However …

Accurate predictions of DNA stability in physiological and enzyme buffers are important for
the design of many biological and biochemical assays. We therefore investigated the effects …